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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

PF-04457845

HY-14376

(PF 04457845; PF04457845)

PF-04457845

PF-04457845 Chemical Structure

PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $110 In-stock
25 mg $220 In-stock
50 mg $400 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €75 In-stock
5 mg €69 In-stock
10 mg €108 In-stock
25 mg €216 In-stock
50 mg €392 In-stock
100 mg Get quote
200 mg Get quote

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Product name: PF-04457845
Cat. No.: HY-14376

PF-04457845 Data Sheet

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    Purity: 98.20%

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    DataSheet

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    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of PF-04457845

PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.
IC50 value: 7.2 nM
Target: FAAH
It has been well tolerated in human trials even at high dose ranges with no evidence for cognitive dysfunction, and has completed Phase II clinical trials for the treatment of osteoarthritis. From Wikipedia.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 455.43 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C23H20F3N5O2
CAS No 1020315-31-4
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1957 mL 10.9786 mL 21.9573 mL
5 mM 0.4391 mL 2.1957 mL 4.3915 mL
10 mM 0.2196 mL 1.0979 mL 2.1957 mL

Clinical Information of PF-04457845

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
PF-04457845 Pfizer Inc Pain 30-APR-10 30-JUN-10 Phase 1 25-JUL-10
Pfizer Inc Pain 31-MAY-09 31-JUL-09 Phase 1 14-JUL-09
Pfizer Inc Pain 30-NOV-09 31-JAN-10 Phase 1 16-JUL-10
Yale University Cannabis dependence 30-JUN-12 31-DEC-16 Phase 2 17-SEP-13
Pfizer Inc 28-FEB-09 31-JUL-09 Phase 1 14-SEP-13
Pfizer Inc Pain 30-NOV-09 31-MAY-10 Phase 2 27-NOV-12

References on PF-04457845

Inhibitor Kit

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