1. Metabolic Enzyme/Protease
  2. DGAT

PF-04620110 (Synonyms: PF 04620110; PF04620110)

Cat. No.: HY-13009 Purity: 99.55%
Handling Instructions

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

For research use only. We do not sell to patients.
PF-04620110 Chemical Structure

PF-04620110 Chemical Structure

CAS No. : 1109276-89-2

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $120 In-stock
10 mg $109 In-stock
50 mg $438 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

Featured Recommendations

Related Screening Libraries:

Related Small Molecules:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

Description

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. IC50 value: 19 nM [1] Target: DGAT1 PF-04620110 and imipramine (internal standard) were separated using a Hypersil Gold C18 column, with a mixture of acetonitrile and 10 mm ammonium formate (90:10, v/v) as the mobile phase. The ion transitions monitored in positive-ion mode [M + H](+) of multiple-reaction monitoring were m/z 397.0 -260.2 for PF-04620110 and m/z 280.8 - 86.0 for imipramine. The detector response was specific and linear for PF-04620110 at concentrations within the range 0.05-50 μg/mL and the signal-to-noise ratios for the samples were ≥10 [2].

Clinical Trial
Sponsor Condition Start Date Phase
Pfizer Inc Non-insulin dependent diabetes 2011-02-28 Phase 1
Pfizer Inc Obesity 2011-06-30 Phase 1
Pfizer Inc Non-insulin dependent diabetes 2010-07-31 Phase 1
Pfizer Inc Obesity 2010-07-31 Phase 1
Pfizer Inc Non-insulin dependent diabetes 2010-06-30 Phase 1
Pfizer Inc Obesity 2010-06-30 Phase 1
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.5224 mL 12.6122 mL 25.2245 mL
5 mM 0.5045 mL 2.5224 mL 5.0449 mL
10 mM 0.2522 mL 1.2612 mL 2.5224 mL
M.Wt

396.44

Formula

C₂₁H₂₄N₄O₄

CAS No.

1109276-89-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

Purity: 99.55%

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PF-04620110
Cat. No.:
HY-13009
Quantity: