1. Metabolic Enzyme/Protease
  2. DGAT

PF-04620110 (Synonyms: PF 04620110; PF04620110)

Cat. No.: HY-13009 Purity: 99.55%
Data Sheet SDS Handling Instructions

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

For research use only. We do not sell to patients.
PF-04620110 Chemical Structure

PF-04620110 Chemical Structure

CAS No. : 1109276-89-2

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Free sample   Apply now  
10 mM * 1 mL in DMSO $120 In-stock
10 mg $109 In-stock
50 mg $438 In-stock
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Description

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. IC50 value: 19 nM [1] Target: DGAT1 PF-04620110 and imipramine (internal standard) were separated using a Hypersil Gold C18 column, with a mixture of acetonitrile and 10 mm ammonium formate (90:10, v/v) as the mobile phase. The ion transitions monitored in positive-ion mode [M + H](+) of multiple-reaction monitoring were m/z 397.0 -260.2 for PF-04620110 and m/z 280.8 - 86.0 for imipramine. The detector response was specific and linear for PF-04620110 at concentrations within the range 0.05-50 μg/mL and the signal-to-noise ratios for the samples were ≥10 [2].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00959426 Pfizer|Bristol-Myers Squibb Obesity|Overweight|Healthy August 2009 Phase 1
NCT00799006 Pfizer Overweight November 2008 Phase 1
NCT01146327 Pfizer|Bristol-Myers Squibb Healthy June 2010 Phase 1
NCT01298518 Pfizer Type 2 Diabetes Patients February 2011 Phase 1
NCT01064492 Pfizer Healthy Volunteers February 2010 Phase 1
NCT01166217 Pfizer|Bristol-Myers Squibb Healthy July 2010 Phase 1
NCT01474941 Pfizer Healthy June 2011 Phase 1
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References
M.Wt

396.44

Formula

C₂₁H₂₄N₄O₄

CAS No.

1109276-89-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
PF-04620110
Cat. No.:
HY-13009
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