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PF-04620110

HY-13009

(PF 04620110; PF04620110)

PF-04620110

PF-04620110 Chemical Structure

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $120 In-stock
10 mg $109 In-stock
50 mg $438 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €118 In-stock
10 mg €107 In-stock
50 mg €429 In-stock
100 mg Get quote
200 mg Get quote

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Product name: PF-04620110
Cat. No.: HY-13009

PF-04620110 Data Sheet

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    Purity: 99.82%

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    DataSheet

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    MSDS

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    COA

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    NMR

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    HPLC

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    LCMS

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Biological Activity of PF-04620110

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
IC50 value: 19 nM [1]
Target: DGAT1
PF-04620110 and imipramine (internal standard) were separated using a Hypersil Gold C18 column, with a mixture of acetonitrile and 10 mm ammonium formate (90:10, v/v) as the mobile phase. The ion transitions monitored in positive-ion mode [M + H](+) of multiple-reaction monitoring were m/z 397.0 → 260.2 for PF-04620110 and m/z 280.8 → 86.0 for imipramine. The detector response was specific and linear for PF-04620110 at concentrations within the range 0.05-50 μg/mL and the signal-to-noise ratios for the samples were ≥10 [2].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 396.44 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C21H24N4O4
CAS No 1109276-89-2
Solvent & Solubility

in DMSO > 10 mM

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5224 mL 12.6122 mL 25.2245 mL
5 mM 0.5045 mL 2.5224 mL 5.0449 mL
10 mM 0.2522 mL 1.2612 mL 2.5224 mL

Clinical Information of PF-04620110

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
PF-04620110 Pfizer Inc Non-insulin dependent diabetes 31-JUL-10 31-AUG-10 Phase 1 13-SEP-13
Pfizer Inc Obesity 31-JUL-10 31-AUG-10 Phase 1 13-SEP-13
Pfizer Inc Obesity 30-JUN-10 01-JAN-11 Phase 1 14-SEP-13
Pfizer Inc Non-insulin dependent diabetes 30-JUN-10 01-JAN-11 Phase 1 14-SEP-13
Pfizer Inc Obesity 30-JUN-11 31-AUG-11 Phase 1 14-SEP-13
Pfizer Inc Non-insulin dependent diabetes 28-FEB-11 01-MAY-11 Phase 1 14-SEP-13

References on PF-04620110

Inhibitor Kit

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