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Signaling Pathway

YK-4-279

HY-14507

(YK 4-279)

YK-4-279

YK-4-279 Chemical Structure

YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
10 mg $80 In-stock
50 mg $308 In-stock
100 mg $565 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €86 In-stock
10 mg €78 In-stock
50 mg €302 In-stock
100 mg €554 In-stock
200 mg Get quote
500 mg Get quote

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Product name: YK-4-279
Cat. No.: HY-14507

YK-4-279 Data Sheet

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    Purity: 99.86%

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    DataSheet

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    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of YK-4-279

YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis.
IC50 value:
Target: RNA Helicase A
ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 μM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 366.2 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C17H13Cl2NO4
CAS No 1037184-44-3
Solvent & Solubility

DMSO ≥100mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.7307 mL 13.6537 mL 27.3075 mL
5 mM 0.5461 mL 2.7307 mL 5.4615 mL
10 mM 0.2731 mL 1.3654 mL 2.7307 mL

References on YK-4-279

Inhibitor Kit