1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis

YK-4-279 (Synonyms: YK 4-279)

Cat. No.: HY-14507
Handling Instructions

YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis.

For research use only. We do not sell to patients.
YK-4-279 Chemical Structure

YK-4-279 Chemical Structure

CAS No. : 1037184-44-3

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
10 mg $80 In-stock
50 mg $308 In-stock
100 mg $565 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis. IC50 value: Target: RNA Helicase A ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 μM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.

Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.7307 mL 13.6537 mL 27.3075 mL
5 mM 0.5461 mL 2.7307 mL 5.4615 mL
10 mM 0.2731 mL 1.3654 mL 2.7307 mL
M.Wt

366.2

Formula

C₁₇H₁₃Cl₂NO₄

CAS No.

1037184-44-3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

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Product Name:
YK-4-279
Cat. No.:
HY-14507
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