1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

Debio 0932 (Synonyms: CUDC-305)

Cat. No.: HY-13469 Purity: 99.44%
Data Sheet SDS Handling Instructions

Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L).

For research use only. We do not sell to patients.
Debio 0932 Chemical Structure

Debio 0932 Chemical Structure

CAS No. : 1061318-81-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO $121 In-stock
5 mg $110 In-stock
10 mg $170 In-stock
50 mg $550 In-stock
100 mg $850 In-stock
200 mg $1300 In-stock
500 mg   Get quote  
1 g   Get quote  

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  • Biological Activity

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Description

Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L) [1]. target: HSP90 [1] IC50: 220 nmol/L [1] in vitro: H1993 and H1975 NSCLC cells were incubated with 1 μmol/L CUDC-305 for 7 hours and then cultured in compound-free medium for an additional 0, 17, or 24 hours, respectively, before being analyzed by Western blot [1] in vivo: CUDC-305 was delivered through oral gavage on an every-other-day (once every two days) dosing schedule at various doses up to 160 mg/kg-its maximum tolerated dose in nude mice. In survival studies in Balb/C nude mice, the highest dose was reduced to 120 mg/kg as a result of the compromised animal condition due to lung and brain tumor implantation surgeries. [1]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01168752 Debiopharm International SA Cancer|Neoplasms|Solid Tumors|Lymphoma April 2010 Phase 1
NCT01714037 Debiopharm International SA|INC Research Non-small Cell Lung Cancer August 2012 Phase 1
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References
Molecular Weight

442.58

Formula

C₂₂H₃₀N₆O₂S

CAS No.

1061318-81-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 33 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.44%

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Product Name:
Debio 0932
Cat. No.:
HY-13469
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