1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

HSP

HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

HSP Related Products (28):

Cat. No. Product Name Effect Purity
  • HY-10211
    17-AAG Inhibitor 98.45%
    17-AAG(NSC 330507; CP 127374) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
  • HY-32735
    Triptolide Inhibitor 99.83%
    Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM.
  • HY-10215
    NVP-AUY922 Inhibitor 98.17%
    NVP-AUY922 is a highly potent HSP90 inhibitor with IC50 of 13 nM/21 nM for for HSP90α/β, respectively, and has weaker potency against the HSP90 family members GRP94 and TRAP-1.
  • HY-15205
    Ganetespib Inhibitor 99.56%
    Ganetespib is a unique non-geldanamycin heat shock protein 90 (HSP90) inhibitor, with IC50 of 4 nM in OSA 8 cells.
  • HY-15230
    Geldanamycin Inhibitor 99.78%
    Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM.
  • HY-101712
    TRC051384 Activator
    TRC051384 is a heat shock protein 70 (HSP70) inducer.
  • HY-12622
    HSP70-IN-1 Inhibitor 98.05%
    HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
  • HY-19356
    Rocaglamide Inhibitor 99.40%
    Rocaglamide is potent and selective for heat shock reporter (IC50 of 50 nM) and for the control reporter (IC50>1000 nM).
  • HY-B0779
    Teprenone Activator 99.91%
    Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins.
  • HY-10941
    VER-155008 Inhibitor 98.83%
    VER-155008 is a novel, small molecule inhibitor of Hsc70/Hsp70 with GI50 of 5.3-14.4 uM in human breast and colon cancer cell lines.
  • HY-12024
    Alvespimycin hydrochloride Inhibitor 99.32%
    Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
  • HY-10210
    Retaspimycin Hydrochloride Inhibitor
    Retaspimycin hydrochloride is a novel and highly soluble inhibitor of the Hsp90 ATPase activity.
  • HY-14463
    AT13387 Inhibitor 99.64%
    AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity.
  • HY-10212
    BIIB021 Inhibitor 99.62%
    BIIB021 is an orally available, fully synthetic inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.
  • HY-13469
    Debio 0932 Inhibitor 99.21%
    Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L).
  • HY-15190
    NVP-HSP990 Inhibitor 98.07%
    NVP-HSP990(HSP990) is an orally bioavailable inhibitor of Hsp90(IC50=13 nM; Hsp90α) with potential antineoplastic activity.
  • HY-10942
    NVP-BEP800 Inhibitor 99.48%
    NVP-BEP800(VER82576) is a novel, fully synthetic, oral Hsp90 inhibitor with an IC50 of 0.058 ± 0.006 μM.
  • HY-18680
    PU-WS13 Inhibitor
    PU-WS13 is a potent, Grp94-specific Hsp90 inhibitor of the purine scaffold class.
  • HY-15098
    Apoptozole Inhibitor 99.57%
    Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity.
  • HY-100872
    KRIBB11 Inhibitor 99.04%
    KRIBB11 is an inhibitor of Heat shock factor (HSF), with IC50 of 1.2 μM.