2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP Endogenous Metabolite
  4. Palmitic acid

Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model.

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Palmitic acid Chemical Structure

Palmitic acid Chemical Structure

CAS No. : 57-10-3

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Based on 33 publication(s) in Google Scholar

Other Forms of Palmitic acid:

Palmitic acid Related Antibodies

Top Publications Citing Use of Products

30 Publications Citing Use of MCE Palmitic acid

WB
IP

    Palmitic acid purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26.  [Abstract]

    Palmitic acid (PA; 100 μM; 24 h) suppresses the interactions between β-catenin and CK1, GSK3, and β-TrCP in HEK293T cells (transfected with Flag-CK1 and Flag-GSK3β).

    Palmitic acid purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26.  [Abstract]

    Palmitic acid (PA; 50, 100, 200 μM; 24 h) decreases endogenous β-catenin polyubiquitination in a dose-dependent manner, in HEK293T cells.

    Palmitic acid purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26.  [Abstract]

    Palmitic acid (PA; 20 or 100 μM; 24 h) rescues ACOX1-mediated β-catenin inhibition in HCT15 cells (transfected with Flag-ACOX1 plasmid).

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model[1][2].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    Palmitic acid (0.1, 0.25 or 0.5 mM; 12-72 h) increases the mRNA levels of Notch1, −2 and −4 in LX2, Huh7 and MIHA hepatic cell lines[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Palmitic acid Related Antibodies
    Clinical Trial
    Molecular Weight

    256.42

    Formula

    C16H32O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CCCCCCCCCCCCCCCC(O)=O
    Structure Classification
    Initial Source

    Widespread
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    Ethanol : 12.82 mg/mL (50.00 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.8999 mL 19.4993 mL 38.9985 mL
    5 mM 0.7800 mL 3.8999 mL 7.7997 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 10 mg/mL (39.00 mM); Suspended solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (9.75 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.76%

    COA (238 KB) HNMR (232 KB) GC (176 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol 1 mM 3.8999 mL 19.4993 mL 38.9985 mL 97.4963 mL
    5 mM 0.7800 mL 3.8999 mL 7.7997 mL 19.4993 mL
    10 mM 0.3900 mL 1.9499 mL 3.8999 mL 9.7496 mL
    15 mM 0.2600 mL 1.3000 mL 2.5999 mL 6.4998 mL
    20 mM 0.1950 mL 0.9750 mL 1.9499 mL 4.8748 mL
    25 mM 0.1560 mL 0.7800 mL 1.5599 mL 3.8999 mL
    30 mM 0.1300 mL 0.6500 mL 1.3000 mL 3.2499 mL
    40 mM 0.0975 mL 0.4875 mL 0.9750 mL 2.4374 mL
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    Palmitic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Palmitic acid57-10-3HSPEndogenous MetaboliteHeat shock proteinsInhibitorinhibitorinhibit

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