2. Immunology/Inflammation
  3. P-selectin
  4. PSI-697

PSI-697  (Synonyms: P-Selectin Inhibitor)

製品番号: HY-15526 純度: 99.79%
COA 取扱説明書 Technical Support

PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM.

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CAS 番号 : 851546-61-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 462 在庫あり
Solution
10 mM * 1 mL in DMSO USD 462 在庫あり
Solid
1 mg $168 在庫あり
5 mg $420 在庫あり
10 mg $600 在庫あり
50 mg $1800 在庫あり
100 mg $2520 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 9 publication(s) in Google Scholar

PSI-697 関連抗体

Top Publications Citing Use of Products

    PSI-697 purchased from MedChemExpress. Usage Cited in: Chem Eng J. 382 (2020) 122848.

    Localization of NPs in H22 bearing tumor tissues. Mice bearing H22 tumors are intravenously injected with PLTM-HMnO2@Cur NPs and PSI-697 pre-treated (20 μg mL-1, 1 h) PLTM-HMnO2@Cur NPs. 24 h later, the tumors were removed and sectioned under frozen conditions followed by staining with an antibody against CD44 (green).

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    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].

    IC50 & Target

    IC50: 125 μM (P-selectin)[1]
    体外実験

    PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    PSI-697 関連抗体
    体内実験

    PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control[1].
    PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model[1].
    PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis[2].
    PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 4-5 weeks male Sprague-Dawley rat (50-100 g)[1]
    Dosage: 0 mg/kg, 30 mg/kg, 50 mg/kg
    Administration: Oral administration
    Result: At an oral dose of 50 mg/kg reduced the number of rolling leukocytes by 39% versus vehicle control.
    臨床実験
    分子量

    367.83

    分子式

    C21H18ClNO3
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(C1=C(O)C(CC2=CC=C(Cl)C=C2)=NC3=C(CCCC4)C4=CC=C13)O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 45.8 mg/mL (124.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7186 mL 13.5932 mL 27.1865 mL
    5 mM 0.5437 mL 2.7186 mL 5.4373 mL
    10 mM 0.2719 mL 1.3593 mL 2.7186 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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    純度とドキュメンテーション

    純度: 99.79%

    COA (256 KB) HNMR (246 KB) RP-HPLC (246 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7186 mL 13.5932 mL 27.1865 mL 67.9662 mL
    5 mM 0.5437 mL 2.7186 mL 5.4373 mL 13.5932 mL
    10 mM 0.2719 mL 1.3593 mL 2.7186 mL 6.7966 mL
    15 mM 0.1812 mL 0.9062 mL 1.8124 mL 4.5311 mL
    20 mM 0.1359 mL 0.6797 mL 1.3593 mL 3.3983 mL
    25 mM 0.1087 mL 0.5437 mL 1.0875 mL 2.7186 mL
    30 mM 0.0906 mL 0.4531 mL 0.9062 mL 2.2655 mL
    40 mM 0.0680 mL 0.3398 mL 0.6797 mL 1.6992 mL
    50 mM 0.0544 mL 0.2719 mL 0.5437 mL 1.3593 mL
    60 mM 0.0453 mL 0.2266 mL 0.4531 mL 1.1328 mL
    80 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8496 mL
    100 mM 0.0272 mL 0.1359 mL 0.2719 mL 0.6797 mL
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    PSI-697 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    PSI-697851546-61-7P-Selectin InhibitorPSI697PSI 697P-selectinCD62Inhibitorinhibitorinhibit

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    製品名:
    PSI-697
    製品番号:
    HY-15526
    数量:
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