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KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM .
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion .
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease .
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects .
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects .
Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM . Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo .
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research .
Odatroltide, as a nanoscale P-selectin inhibitor, is a nano-delivery system of 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to target the thrombus .
TRAP-6-IN-1 (Compound 8) is a dual collagen and TRAP-6 inhibitor with IC50 values of 17.12 µM and 11.88 µM against collagen and TRAP-6, respectively. TRAP-6-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner .
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment .
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .
Lewis X trisaccharide (Lewis X, Le x) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion .
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease .
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .
Lewis X trisaccharide (Lewis X, Le x) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .
P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes. It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X. P-Selectin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of P-Selectin Protein, Mouse (HEK293, Fc) is 668 a.a., with molecular weight of ~135 kDa.
P-Selectin, a Ca(2+)-dependent receptor on myeloid cells, binds to neutrophils and monocytes via carbohydrates. It interacts with SELPLG to enable rapid leukocyte rolling over vascular surfaces in early inflammation. P-Selectin also interacts with SNX17 and promotes neutrophil adhesion and rolling, requiring SELPLG's sialyl-Lewis X and tyrosine sulfation. P-Selectin Protein, Rat (HEK293, His) is the recombinant rat-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-Selectin Protein, Rat (HEK293, His) is 659 a.a., with molecular weight of ~115 kDa.
P-Selectin, a Ca(2+)-dependent receptor on myeloid cells, binds to neutrophils and monocytes via carbohydrates. It interacts with SELPLG to enable rapid leukocyte rolling over vascular surfaces in early inflammation. P-Selectin also interacts with SNX17 and promotes neutrophil adhesion and rolling, requiring SELPLG's sialyl-Lewis X and tyrosine sulfation. P-Selectin Protein, Rat (HEK293, Fc) is the recombinant rat-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of P-Selectin Protein, Rat (HEK293, Fc) is 659 a.a., with molecular weight of ~98.7 kDa.
P-selectin, a Ca(2+)-dependent receptor on myeloid cells, crucially binds to sialyl-Lewis X on neutrophils and monocytes, facilitating the interaction of activated endothelial cells or platelets with leukocytes. This engagement, primarily with SELPLG/PSGL1 and PODXL2, is vital for the rapid rolling of leukocytes during early inflammation. P-selectin's interactions with SNX17 further mediate neutrophil adhesion and rolling, dependent on the sialyl-Lewis X epitope and specific tyrosine sulfation on SELPLG. P-Selectin Protein, Human (HEK293, Fc) is the recombinant human-derived P-Selectin protein, expressed by HEK293, with C-hFc labeled tag. The total length of P-Selectin Protein, Human (HEK293, Fc) is 730 a.a., with molecular weight of 130-150 kDa.
P-Selectin Protein, Rhesus Macaque (HEK293, His) is a member of the selectin family of cell adhesion molecules. P-selectin (CD62P) has an N-terminal lectin domain, an epidermal growth factor motif, (generally) nine regulatory protein repeats, a transmembrane section and a short intracytoplasmic tail. P-selectin mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. P-selectin glycoprotein ligand-1 (PSGL-1) is a major ligand for P-selectin. P-Selectin Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-Selectin Protein, Rhesus Macaque (HEK293, His) is 730 a.a., with molecular weight of ~81.2 kDa.
P-Selectin Protein, Rhesus Macaque (HEK293, His) is a member of the selectin family of cell adhesion molecules. P-selectin (CD62P) has an N-terminal lectin domain, an epidermal growth factor motif, (generally) nine regulatory protein repeats, a transmembrane section and a short intracytoplasmic tail. P-selectin mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. P-selectin glycoprotein ligand-1 (PSGL-1) is a major ligand for P-selectin. P-Selectin Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of P-Selectin Protein, Rhesus Macaque (HEK293, Fc) is 730 a.a., with molecular weight of ~106.8 kDa.
P-selectin is a Ca(2+)-dependent receptor on myeloid cells that critically binds to sialic acid-Lewis X on neutrophils and monocytes, promoting the interaction between activated endothelial cells or platelets and leukocytes interaction. This binding primarily to SELPLG/PSGL1 and PODXL2 is critical for rapid rolling of leukocytes during early inflammation. P-selectin Protein, Human (HEK293, His) is the recombinant human-derived P-selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-selectin Protein, Human (HEK293, His) is 730 a.a., with molecular weight of 95-130 kDa.
P-selectin, a Ca(2+)-dependent receptor on myeloid cells, binds specifically to carbohydrates on neutrophils and monocytes. It mediates interaction between activated endothelial cells or platelets and leukocytes through recognition of sialyl-Lewis X. P-selectin facilitates leukocyte rolling over vascular surfaces during inflammation by interacting with SELPLG and SNX17. It also promotes neutrophil adhesion and leukocyte rolling through interactions with SELPLG/PSGL1 and PODXL2, requiring sialyl-Lewis X and tyrosine sulfation on SELPLG. P-Selectin Protein, Mouse (HEK293, His) is the recombinant mouse-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-Selectin Protein, Mouse (HEK293, His) is 668 a.a., with molecular weight of 110-130 kDa.
P-selectin, a Ca(2+)-dependent receptor on myeloid cells, crucially binds to sialyl-Lewis X on neutrophils and monocytes, facilitating the interaction of activated endothelial cells or platelets with leukocytes. This engagement, primarily with SELPLG/PSGL1 and PODXL2, is vital for the rapid rolling of leukocytes during early inflammation. P-selectin's interactions with SNX17 further mediate neutrophil adhesion and rolling, dependent on the sialyl-Lewis X epitope and specific tyrosine sulfation on SELPLG. P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived P-Selectin protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) is 730 a.a., with molecular weight of 115-140 kDa.
P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes. It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X. P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) is the recombinant mouse-derived P-selectin protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) is 668 a.a., with molecular weight of 102-122 kDa.
CD162/PSGL-1 protein, an SLe(x)-type proteoglycan, facilitates early inflammation stages by mediating rapid leukocyte rolling through high-affinity interactions with E- and P-selectins. CD162 forms homodimers linked by disulfide bonds, interacting with selectins through lectin/EGF domains. For high-affinity P-selectin binding, sialyl Lewis X glycan modification and tyrosine sulfation, likely on Tyr-54, are required. Dimerization seems dispensable. CD162 also interacts with SNX20, mediating SYK activation, and with MSN and SYK, contributing to downstream signaling events. Its engagement with HAVCR1 reveals diverse cellular interactions. CD162/PSGL-1 Protein, Mouse (HEK293) is the recombinant mouse-derived CD162/PSGL-1 protein, expressed by HEK293, with tag free. The total length of CD162/PSGL-1 Protein, Mouse (HEK293) is 307 a.a., with molecular weight of ~54.9 kDa.
CD162/PSGL-1 Protein, a cell surface receptor, plays a crucial role in leukocyte trafficking and adhesion. Dysregulation of CD162/PSGL-1 Protein has been associated with inflammatory diseases and impaired immune responses. Targeting CD162/PSGL-1 Protein may offer potential therapeutic interventions in these conditions by modulating leukocyte trafficking, enhancing immune responses, and managing inflammatory disorders. CD162/PSGL-1 Protein, Human (HEK293, His) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293, with C-His labeled tag. The total length of CD162/PSGL-1 Protein, Human (HEK293, His) is 295 a.a., with molecular weight of ~89 & 61 kDa, respectively.
CD162/PSGL-1 Protein, a cell surface receptor, plays a crucial role in leukocyte trafficking and adhesion. Dysregulation of CD162/PSGL-1 Protein has been associated with inflammatory diseases and impaired immune responses. Targeting CD162/PSGL-1 Protein may offer potential therapeutic interventions in these conditions by modulating leukocyte trafficking, enhancing immune responses, and managing inflammatory disorders. CD162/PSGL-1 Protein, Human (254a.a, HEK293, Fc) is the recombinant human-derived CD162/PSGL-1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of CD162/PSGL-1 Protein, Human (254a.a, HEK293, Fc) is 254 a.a., with molecular weight of 100-130 kDa.
CD162/PSGL-1 protein, an SLe(x)-type proteoglycan, facilitates early inflammation stages by mediating rapid leukocyte rolling through high-affinity interactions with E- and P-selectins. CD162 forms homodimers linked by disulfide bonds, interacting with selectins through lectin/EGF domains. For high-affinity P-selectin binding, sialyl Lewis X glycan modification and tyrosine sulfation, likely on Tyr-54, are required. Dimerization seems dispensable. CD162 also interacts with SNX20, mediating SYK activation, and with MSN and SYK, contributing to downstream signaling events. Its engagement with HAVCR1 reveals diverse cellular interactions. CD162/PSGL-1 Protein, Mouse (307a.a, HEK293, Fc) is the recombinant mouse-derived CD162/PSGL-1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of CD162/PSGL-1 Protein, Mouse (307a.a, HEK293, Fc) is 307 a.a., with molecular weight of ~82 kDa.