1. Metabolic Enzyme/Protease
  2. Cathepsin

Pepstatin (Synonyms: Pepstatin A; Isovaleryl-Val-Val-Sta-Ala-Sta-OH)

Cat. No.: HY-P0018 Purity: 98.45%
Handling Instructions

Pepstatin is a potent inhibitor of aspartyl proteases, and inhibits the aspartic proteases cathepsin D, pepsin, and renin.

For research use only. We do not sell to patients.
Pepstatin Chemical Structure

Pepstatin Chemical Structure

CAS No. : 26305-03-3

Size Price Stock Quantity
10 mg USD 60 In-stock
50 mg USD 204 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Pepstatin is a potent inhibitor of aspartyl proteases, and inhibits the aspartic proteases cathepsin D, pepsin, and renin.

In Vivo

A low dose of pepstatin shows an inhibition of edema formation, and intraperitoneal injection of 1.25 mg/kg of pepstatin causes a 30% inhibition with a a very low toxicity[1]. Pepstatin increases LC3-II levels, while it is reverted by 3-methyladenine (3-MA)[2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.4580 mL 7.2898 mL 14.5796 mL
5 mM 0.2916 mL 1.4580 mL 2.9159 mL
10 mM 0.1458 mL 0.7290 mL 1.4580 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

685.89

Formula

C₃₄H₆₃N₅O₉

CAS No.

26305-03-3

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 25 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.45%

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Product Name:
Pepstatin
Cat. No.:
HY-P0018
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