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A-443654

HY-10425

(A 443654; A443654)

A-443654

A-443654 Chemical Structure

A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $395 In-stock
5 mg $359 In-stock
10 mg Get quote
50 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €387 In-stock
5 mg €352 In-stock
10 mg Get quote
50 mg Get quote

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Product name: A-443654
Cat. No.: HY-10425

A-443654 Data Sheet

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    Purity: 99.90%

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Biological Activity of A-443654

A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines.
IC50 value: 0.16 nM(Ki, Akt1) [1]
Target: pan-Akt
A-443654 (Ki = 160 pmol/L versus Akt1) inhibits Akt-dependent signal transduction in cells and in vivo in a dose-responsive manner [1]. Rapamycin and A-443654 in combination produced the greatest morphological changes and inhibited cell proliferation by G2/M arrest. Rapamycin and A-443654 in combination induced apoptosis at earlier times and at lower A-443654 concentrations in MCF10CA1a tumor cells than in the benign MCF10A cells [2]. One small molecule, A-443654, showed the greatest selective inhibition of cells with the mutant phenotype. Based on these findings, this inhibitor was screened in vitro against a panel of glioblastoma multiforme cell lines. All cell lines tested were sensitive to A-443654 with a mean IC(50) of approximately 150 nmol/L [3].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 397.47 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C24H23N5O
CAS No 552325-16-3
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5159 mL 12.5796 mL 25.1591 mL
5 mM 0.5032 mL 2.5159 mL 5.0318 mL
10 mM 0.2516 mL 1.2580 mL 2.5159 mL

References on A-443654

Inhibitor Kit

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