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Products are for research use only. Not for human use. We do not sell to patients.
(A 443654; A443654)
A-443654 Chemical Structure
|Product name: A-443654|
|Cat. No.: HY-10425|
A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines.
IC50 value: 0.16 nM(Ki, Akt1) 
A-443654 (Ki = 160 pmol/L versus Akt1) inhibits Akt-dependent signal transduction in cells and in vivo in a dose-responsive manner . Rapamycin and A-443654 in combination produced the greatest morphological changes and inhibited cell proliferation by G2/M arrest. Rapamycin and A-443654 in combination induced apoptosis at earlier times and at lower A-443654 concentrations in MCF10CA1a tumor cells than in the benign MCF10A cells . One small molecule, A-443654, showed the greatest selective inhibition of cells with the mutant phenotype. Based on these findings, this inhibitor was screened in vitro against a panel of glioblastoma multiforme cell lines. All cell lines tested were sensitive to A-443654 with a mean IC(50) of approximately 150 nmol/L .
|M.Wt||397.47||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||2.5159 mL||12.5796 mL||25.1591 mL|
|5 mM||0.5032 mL||2.5159 mL||5.0318 mL|
|10 mM||0.2516 mL||1.2580 mL||2.5159 mL|
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