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Products are for research use only. Not for human use. We do not sell to patients.
(BIX 01294; BIX01294)
BIX-01294 Chemical Structure
|Product name: BIX-01294|
|Cat. No.: HY-10587|
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.
IC50 Value: 2.7 μM
BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. In its inhibition of the histone lysine methyltransferases, BIX-01294 does not compete with cofactor S-adenosyl-methionine. G9a HMTase regulates gene expression including one of the pluripotency genes Oct4. It is reported that BIX-01294 enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. BIX-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.
|M.Wt||490.64||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO 98 mg/mL; Water 98 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.0382 mL||10.1908 mL||20.3815 mL|
|5 mM||0.4076 mL||2.0382 mL||4.0763 mL|
|10 mM||0.2038 mL||1.0191 mL||2.0382 mL|
. Park KE, Johnson CM, Cabot RA. IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo. Reprod Fertil Dev. 2012;24(6):813-21.
. Yang Q, Lu Z, Singh D, Raj JU. BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells. Cell Prolif. 2012 Aug;45(4):335-44.
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