Search Result

Isoforms Recommended:	PRMT1

Results for "

PRMT1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (2) Histone Methyltransferase (28) Parasite (2) Phosphodiesterase (PDE) (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (28) Infection (2) Inflammation/Immunology (3)

Inhibitors & Agonists

Peptides

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122096

DCLX069 1 Publications Verification	Histone Methyltransferase	Cancer
DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects ^[1].

HY-RS11167

PRMT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRMT1 Human Pre-designed siRNA Set A PRMT1 Human Pre-designed siRNA Set A

HY-RS11168

Prmt1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt1 Mouse Pre-designed siRNA Set A Prmt1 Mouse Pre-designed siRNA Set A

HY-RS11169

Prmt1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prmt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt1 Rat Pre-designed siRNA Set A Prmt1 Rat Pre-designed siRNA Set A

HY-115758

PRMT1-IN-1

Histone Methyltransferase Cancer

PRMT1-IN-1 is a PRMT1 inhibitor.

PRMT1-IN-1	Histone Methyltransferase	Cancer
PRMT1-IN-1 is a PRMT1 inhibitor.

HY-157151

iPRMT1	Histone Methyltransferase	Cancer
iPRMT1 is a potent and selective *PRMT1* inhibitor for breast cancer research. iPRMT1 inhibits breast cancer cell growth in vitro and in vivo with EC₅₀ values of 90, 70, and 9 nM in MCF7, T47D, and MDA-MB-231 cells, respectively ^[1].

HY-P1182

C21

Histone Methyltransferase Cancer

C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM ^[1].

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective *PRMT1* inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM ^[1].

HY-110137A

Furamidine DB75; NSC 305831	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine (DB75) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine is selective for *PRMT1* over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of *TDP-1* by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent ^[1] .

HY-110137

Furamidine dihydrochloride 1 Publications Verification DB75 dihydrochloride; NSC 305831 dihydrochloride	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine dihydrochloride is selective for *PRMT1* over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of *TDP-1* by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent ^[1] .

HY-18962

AMI-1	Histone Methyltransferase	Cancer
AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC₅₀s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding ^[1].

HY-15890

C-7280948

Histone Methyltransferase Cancer

C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC₅₀ value of 12.75 μM ^[1].

C-7280948	Histone Methyltransferase	Cancer
C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC₅₀ value of 12.75 μM ^[1].

HY-18962A

AMI-1 free acid 3 Publications Verification	Histone Methyltransferase	Cancer
AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC₅₀s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding ^[1].

HY-107574

TC-E 5003	Histone Methyltransferase	Inflammation/Immunology
TC-E 5003 is a selective *PRMT1* inhibitor with an IC₅₀ of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory properties in TLR4 signaling ^[1] .

HY-12970A

EPZ020411 hydrochloride 5 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
EPZ020411 hydrochloride is a selective inhibitor of *PRMT6* with an IC₅₀ of 10 nM, it has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 hydrochloride can be used for the research of cancer ^[1] .

HY-12970

EPZ020411 5 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
EPZ020411 is a selective inhibitor of *PRMT6* with an IC₅₀ of 10 nM, has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 can be used for the research of cancer ^[1] .

HY-161334

CARM1-IN-4	Histone Methyltransferase Apoptosis	Cancer
CARM1-IN-4 (compound 11f) is a potent *CARM1* inhibitor with IC₅₀s of 9 nM and 56 nM for CARM1 and PRMT1, respectively. CARM1-IN-4 displays significant anti-proliferative effects on colorectal cancer cell lines. CARM1-IN-4 effectively inhibits the methyltransferase activity of CARM1 and prevents methylation of downstream proteins. CARM1-IN-4 induces apoptosis and shows antitumor activity ^[1].

HY-12759A

CARM1-IN-1 hydrochloride 1 Publications Verification	Histone Methyltransferase	Cancer
CARM1-IN-1 hydrochloride is a potent and specific *CARM1* (Coactivator-associated arginine methyltransferase 1) inhibitor with IC₅₀ of 8.6 uM; shows very low activity against PRMT1 and SET7.

HY-162003

DCPT1061	Histone Methyltransferase	Cancer
DCPT1061 potently inhibits PRMT1, PRMT6 and PRMT8 in vitro with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. DCPT1061 has antitumor effect ^[1] .

HY-162003A

DCPT1061 hydrochloride	Histone Methyltransferase	Cancer
DCPT1061 hydrochloride has a strong inhibitory effect on *PRMT1, PRMT6, and PRMT8* in vitro, The epigenetic enzymes such as *PRMT3, PRMT4* and *PRMT5* had little inhibitory effect. DCPT1061 hydrochloride has antitumor effects ^[1] .

HY-155154

PRMT4-IN-2	Others	Cancer
PRMT4-IN-2 (compound 55) is a pan-inhibitor of protein arginine methyltransferase (PRMT) with IC₅₀s of 92 nM (PRMT4), 436 nM (PRMT6), 460 nM (PRMT1), 823 nM ( PRMT8), 1.386 μM (PRMT3) ^[1].

HY-12759

CARM1-IN-1 1 Publications Verification	Histone Methyltransferase	Cancer
CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).

HY-19615

MS023 5+ Cited Publications	Histone Methyltransferase	Cancer
MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively ^[1].

HY-19615B

MS023 dihydrochloride 5+ Cited Publications	Histone Methyltransferase	Cancer
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively ^[1].

HY-19615A

MS023 trihydrochloride	Histone Methyltransferase	Cancer
MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively ^[1].

HY-100855

DC_C66	Histone Methyltransferase	Cancer
DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC₅₀ of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC₅₀=21 μM), PRMT6 (IC₅₀= 47μM), and PRMT5 ^[1].

HY-128717

GSK3368715 EPZ019997	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity ^[1].

HY-128717A

GSK3368715 dihydrochloride 10+ Cited Publications EPZ019997 dihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity ^[1].

HY-128717B

GSK3368715 trihydrochloride EPZ019997 trihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 trihydrochloride (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 trihydrochloride (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity ^[1].

HY-120137

CMP-5	Histone Methyltransferase	Cancer
CMP-5 is a potent, specific, and selective *PRMT5* inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected ^[1] .

HY-113846

CMP-5 hydrochloride	Histone Methyltransferase	Cancer
CMP-5 hydrochloride is a potent, specific, and selective *PRMT5* inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected ^[1] .

HY-10587

BIX-01294 Maximum Cited Publications 20 Publications Verification	Histone Methyltransferase Autophagy	Cancer
BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC₅₀s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells ^[1] .

HY-108239

BIX-01294 trihydrochloride	Histone Methyltransferase Autophagy	Cancer
BIX-01294 trihydrochloride is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC₅₀s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 trihydrochloride inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294 trihydrochloride, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 trihydrochloride has antitumor activity in recurrent tumor cells ^[1] .

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective *PRMT1* inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM ^[1].

PRMT1 Antibody (YA686) ANM 1; ANM1; ANM1_HUMAN; complete cds; HCP 1; HCP1; Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like2; Hi	WB	Human
PRMT1 Antibody (YA686) is a non-conjugated and Mouse origined monoclonal antibody about 42 kDa, targeting to PRMT1 (4E9). It can be used for WB assays with tag free, in the background of Human.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: