1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR

CP-466722 

Cat. No.: HY-11002 Purity: 98.40%
Data Sheet SDS Handling Instructions

CP-466722 is rapidly reversible potential ATM kinase inhibitor.

For research use only. We do not sell to patients.
CP-466722 Chemical Structure

CP-466722 Chemical Structure

CAS No. : 1080622-86-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $99 In-stock
5 mg $90 In-stock
10 mg $150 In-stock
50 mg $420 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

CP-466722 is rapidly reversible potential ATM kinase inhibitor. IC50 Value: Target: ATM CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP-466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP-466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP-466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies.

References
M.Wt

349.35

Formula

C₁₇H₁₅N₇O₂

CAS No.

1080622-86-1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 7 mg/mL (Need warming)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.40%

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Product Name:
CP-466722
Cat. No.:
HY-11002
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