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Signaling Pathway



(CP466722; CP 466722)


CP-466722 Chemical Structure

CP-466722 is rapidly reversible potential ATM kinase inhibitor.

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5 mg $90 In-stock
10 mg $150 In-stock
50 mg $420 In-stock
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Size Price Stock Quantity
5 mg €88 In-stock
10 mg €147 In-stock
50 mg €412 In-stock
100 mg Get quote
200 mg Get quote

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Inquiry Information
Product name: CP-466722
Cat. No.: HY-11002

CP-466722 Data Sheet

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    Purity: 98.05%

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Related Compound Libraries

Biological Activity of CP-466722

CP-466722 is rapidly reversible potential ATM kinase inhibitor.
IC50 Value:
Target: ATM
CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP-466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP-466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP-466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies.

Protocol (Extracted from published papers and Only for reference)


Chemical Information

M.Wt 349.35 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C17H15N7O2
CAS No 1080622-86-1
Solvent & Solubility

DMSO: 0.28 mg/mL, H2O: <1 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.8625 mL 14.3123 mL 28.6246 mL
5 mM 0.5725 mL 2.8625 mL 5.7249 mL
10 mM 0.2862 mL 1.4312 mL 2.8625 mL

References on CP-466722

Inhibitor Kit

Related ATM Products

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    CGK 733 is a small molecule inhibitor reportedly targeting the kinase activities of ATM and ATR.

  • KU-55933

    KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively; highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

  • KU-60019

    KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM.

  • Wortmannin

    Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50 of 3 nM and 0.17 (mu)M, respectively.