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Products are for research use only. Not for human use. We do not sell to patients.
(CP466722; CP 466722)
CP-466722 Chemical Structure
|Product name: CP-466722|
|Cat. No.: HY-11002|
CP-466722 is rapidly reversible potential ATM kinase inhibitor.
CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP-466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP-466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP-466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies.
|M.Wt||349.35||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: 0.28 mg/mL, H2O: <1 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.8625 mL||14.3123 mL||28.6246 mL|
|5 mM||0.5725 mL||2.8625 mL||5.7249 mL|
|10 mM||0.2862 mL||1.4312 mL||2.8625 mL|
CGK 733 is a small molecule inhibitor reportedly targeting the kinase activities of ATM and ATR.
KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively; highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM.
Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50 of 3 nM and 0.17 (mu)M, respectively.