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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

KU-57788

HY-11006

(KU 57788; NU-7441; KU57788; NU7441; NU 7441)

KU-57788

KU-57788 Chemical Structure

KU-57788(NU7441) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 value of are 14 nM; 1700, 5000, >100000 and >100000 nM for mTOR, PI 3K, ATM and ATR respectively; also is a modest inhibitor of BRD4 and BRDT with IC50s

Size Price Stock Quantity
10 mM * 1 mL in DMSO $99 In-stock
10 mg $90 In-stock
50 mg $288 In-stock
100 mg $403 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €97 In-stock
10 mg €88 In-stock
50 mg €282 In-stock
100 mg €395 In-stock
200 mg Get quote
500 mg Get quote

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Product name: KU-57788
Cat. No.: HY-11006

KU-57788 Data Sheet

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    Purity: 99.63%

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    Pdf Version

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Biological Activity of KU-57788

KU-57788(NU7441) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 value of  are 14 nM; 1700, 5000, >100000 and >100000 nM for  mTOR, PI 3K, ATM and ATR respectively; also is a modest inhibitor of BRD4 and BRDT with IC50s of 1 and 3.5 uM respectively.
IC50 value: 14 nM (DNA-PK)[1]; 1/3.5 uM(BRD4/BRDT) [4]
Target: DNA-PK; BRD4/BRDT
in vitro:  NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. NU7441 appreciably increased G(2)-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells [2]. NU7441 strongly inhibited DNA-PK in cell lines (IC(50) = 0.3 μM) but only weakly inhibited PI3 K (IC(50) = 7 μM). NU7441 caused doxorubicin- and IR-induced DNA DSBs (measured by γ-H2AX foci) to persist and also slightly decreased homologous recombination activity, as assessed by Rad51 foci [3]. NU7441 is a modest inhibitor of BRD4 and BRDT (IC50 = 1 and 3.5 SM, respectively), which establishes a single hydrogen bond in the KAc site through the chromenone oxygen with Asn140 [4].
in vivo: In mice bearing SW620 xenografts, NU7441 concentrations in the tumor necessary for chemopotentiation in vitro were maintained for at least 4 hours at nontoxic doses. NU7441 increased etoposide-induced tumor growth delay 2-fold without exacerbating etoposide toxicity to unacceptable levels [2].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 413.49 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C25H19NO3S
CAS No 503468-95-9
Solvent & Solubility

DMSO ≥4.8mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.4184 mL 12.0922 mL 24.1844 mL
5 mM 0.4837 mL 2.4184 mL 4.8369 mL
10 mM 0.2418 mL 1.2092 mL 2.4184 mL

References on KU-57788

Inhibitor Kit

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