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Products are for research use only. Not for human use. We do not sell to patients.
(PF 4708671; PF4708671)
PF-4708671 Chemical Structure
|Product name: PF-4708671|
|Cat. No.: HY-15773|
PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM.
IC50 Value: 160 nM 
PF-4708671 is a novel cell-permeable inhibitor of S6K1, which specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR .
|M.Wt||390.41||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO 30 mg/ml; Water < 1 mg/ml
|1 mg||5 mg||10 mg|
|1 mM||2.5614 mL||12.8070 mL||25.6141 mL|
|5 mM||0.5123 mL||2.5614 mL||5.1228 mL|
|10 mM||0.2561 mL||1.2807 mL||2.5614 mL|
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