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PF-4708671

HY-15773

(PF 4708671; PF4708671)

PF-4708671

PF-4708671 Chemical Structure

PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $75 In-stock
10 mg $68 In-stock
50 mg $266 In-stock
100 mg $494 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €74 In-stock
10 mg €67 In-stock
50 mg €261 In-stock
100 mg €484 In-stock
200 mg Get quote
500 mg Get quote

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Product name: PF-4708671
Cat. No.: HY-15773

PF-4708671 Data Sheet

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    Purity: 98.05%

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Related Compound Libraries

Biological Activity of PF-4708671

PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM.
IC50 Value: 160 nM [1]
Target: S6K1
PF-4708671 is a novel cell-permeable inhibitor of S6K1, which specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR [1].
 

Chemical Information

M.Wt 390.41 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C19H21F3N6
CAS No 1255517-76-0
Solvent & Solubility

DMSO 30 mg/ml; Water < 1 mg/ml

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5614 mL 12.8070 mL 25.6141 mL
5 mM 0.5123 mL 2.5614 mL 5.1228 mL
10 mM 0.2561 mL 1.2807 mL 2.5614 mL

References on PF-4708671

Inhibitor Kit
  • BI-D1870

    BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3(beta), MARK3, CK1 and Aurora B. BI-D1870 also has a Kd value of 3.5 uM for BRD4.

  • BIX 02565

    BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM.

  • LJH685

    LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM.

  • LJI308

    LJI308 is a new and potent pan-RSK inhibitor, with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.

  • PI3K-IN-2

    PI3K-IN-2 is a PI3K inhibitor, inhibits pPKB and pS6 with "(addition)(addition)(addition)(addition)/(addition)(addition)(addition)((addition))" in A2058 melanoma cell.