1. MAPK/ERK Pathway
  2. Ribosomal S6 Kinase (RSK)

PF-4708671 (Synonyms: PF 4708671; PF4708671)

Cat. No.: HY-15773
Handling Instructions

PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM.

For research use only. We do not sell to patients.
PF-4708671 Chemical Structure

PF-4708671 Chemical Structure

CAS No. : 1255517-76-0

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10 mM * 1 mL in DMSO $75 In-stock
10 mg $68 In-stock
50 mg $266 In-stock
100 mg $494 In-stock
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Top Publications Citing Use of Products

    PF-4708671 purchased from MCE. Usage Cited in: J Proteomics. 2016 Feb 2;136:13-24.

    mTORC1 regulates KPNA2 transcription but not S6K1- and 4E-BP1-dependent translation. KPNA2 abundances in response to S6K1 inhibition are detected by Western blot analysis in WT and TSC2−/− MEFs.

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    Description

    PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM. IC50 Value: 160 nM [1] Target: S6K1 PF-4708671 is a novel cell-permeable inhibitor of S6K1, which specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR [1].

    References
    Preparing Stock Solutions
    Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
    1 mM 2.5614 mL 12.8070 mL 25.6141 mL
    5 mM 0.5123 mL 2.5614 mL 5.1228 mL
    10 mM 0.2561 mL 1.2807 mL 2.5614 mL
    References
    M.Wt

    390.41

    Formula

    C₁₉H₂₁F₃N₆

    CAS No.

    1255517-76-0

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    PF-4708671
    Cat. No.:
    HY-15773
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