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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

SB 525334

HY-12043

(SB-525334; SB525334)

SB 525334

SB 525334 Chemical Structure

SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.

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10 mM * 1 mL in DMSO $66 In-stock
5 mg $60 In-stock
10 mg $90 In-stock
50 mg $310 In-stock
100 mg $510 In-stock
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Free sample   Apply now  
10 mM * 1 mL in DMSO €65 In-stock
5 mg €59 In-stock
10 mg €88 In-stock
50 mg €304 In-stock
100 mg €500 In-stock
200 mg Get quote
500 mg Get quote

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Product name: SB 525334
Cat. No.: HY-12043

SB 525334 Data Sheet

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    Purity: 99.16%

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Biological Activity of SB 525334

SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
IC50 value: 14.3 nM
Target: ALK5
in vitro: SB 525334 shows no inhibition in the enzymes ALK2, 3, and 6, with IC50 values > 10 μM. SB 525334 blocks phosphorylation induced by TGF-β1 and nuclear translocation of Smad2/3 in renal proximal tubule cells. SB 525334 also inhibits the increased mRNA expression levels of plasminogen activator inhibitor-1 (PAI-1) and procollagen α1(I) induced by TGF-β1 in A498 renal epithelial carcinoma cells at 1 μM) [1]. SB 525334 (1 μM) attenuates the heightened sensitivity to TGF-β1 exhibited by pulmonary artery smooth muscle cells (PASMCs) from patients with familial forms of idiopathic pulmonary arterial hypertension (PAH) [2].
in vivo: SB 525334 (10 mg/kg/day) decreases the renal mRNA levels of PAI-1, procollagen α1(I), and procollagen α1(III) in a nephritis-induced renal fibrosis rat model. Furthermore, PAN-induced proteinuria is significantly inhibited by SB 525334 (10 mg/kg/day) [1]. SB 525334 may also be efficacious in mesenchymal tumors. SB 525334 (10 mg/kg/day) significantly decreases uterine mesenchymal tumor incidence, multiplicity, and size in Eker rats [3].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 343.42 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C21H21N5
CAS No 356559-20-1
Solvent & Solubility

DMSO ≥66mg/mL Water <1.2mg/mL Ethanol ≥66mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.9119 mL 14.5594 mL 29.1189 mL
5 mM 0.5824 mL 2.9119 mL 5.8238 mL
10 mM 0.2912 mL 1.4559 mL 2.9119 mL

References on SB 525334

Inhibitor Kit

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