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Products are for research use only. Not for human use. We do not sell to patients.
(Antibiotic AM-2282; STS; AM-2282)
Staurosporine Chemical Structure
|Product name: Staurosporine|
|Cat. No.: HY-15141|
Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. This lack of specificity has precluded its clinical use, but has made it a valuable research tool. In research, staurosporine is used to induce apoptosis. The mechanism of how it mediates this is not well understood. It has been found that one way in which staurosporine induces apoptosis is by activating caspase-3.
|M.Wt||466.53||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
|1 mg||5 mg||10 mg|
|1 mM||2.1435 mL||10.7174 mL||21.4348 mL|
|5 mM||0.4287 mL||2.1435 mL||4.2870 mL|
|10 mM||0.2143 mL||1.0717 mL||2.1435 mL|
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