1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase

ZM-447439 

Cat. No.: HY-10128 Purity: 98.88%
Data Sheet SDS Handling Instructions

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C, MEK1, Src.

For research use only. We do not sell to patients.
ZM-447439 Chemical Structure

ZM-447439 Chemical Structure

CAS No. : 331771-20-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO $56 In-stock
5 mg $50 In-stock
10 mg $75 In-stock
50 mg $260 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C, MEK1, Src. IC50 Value: 110 nM( for Aurora A); 130 nM (for Aurora B) [1] Target: Aurora Kinase in vitro: ZM-447439 time- and dose-dependently inhibits the growth of all three cell lines with IC50 values of 3 μM (BON), 0.9 μM (QGP-1) and 3 μM (MIP-101) after 72 hours of continuous exposure. In addition, ZM-447439 potently induces cell apoptosis by promoting DNA fragmentation and caspase 3 and 7 activation, and arrests GEP-NET cells in the G0 /G1and G2/M phase of the cell cycle. [2] In mouse embryo, inhibition of Aurora kinase activity by ZM-447439 results in abnormalities during mitosis by regulating the phosphorylation of histone H3 serine 10 (H3S10Ph) from G2 to metaphase with different perturbations in each embryonic cycle. [3] A recent study shows that ZM-447439 exhibits growth inhibitory and proapoptotic effect on cervical cancer SiHa cells, and enhances the chemosensitivity to cisplatin. in vivo:

References
M.Wt

513.59

Formula

C₂₉H₃₁N₅O₄

CAS No.

331771-20-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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ZM-447439
Cat. No.:
HY-10128
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