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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

ZM-447439

HY-10128

(ZM447439; ZM 447439)

ZM-447439

ZM-447439 Chemical Structure

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C,

Size Price Stock Quantity
10 mM * 1 mL in DMSO $95 In-stock
10 mg $86 In-stock
50 mg $288 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €93 In-stock
10 mg €84 In-stock
50 mg €282 In-stock
100 mg Get quote
200 mg Get quote

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Product name: ZM-447439
Cat. No.: HY-10128

ZM-447439 Data Sheet

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    Purity: 98.88%

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Biological Activity of ZM-447439

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C, MEK1, Src.
IC50 Value: 110 nM( for Aurora A); 130 nM (for Aurora B) [1]
Target: Aurora Kinase
in vitro: ZM-447439 time- and dose-dependently inhibits the growth of all three cell lines with IC50 values of 3 μM (BON), 0.9 μM (QGP-1) and 3 μM (MIP-101) after 72 hours of continuous exposure. In addition, ZM-447439 potently induces cell apoptosis by promoting DNA fragmentation and caspase 3 and 7 activation, and arrests GEP-NET cells in the G0 /G1and G2/M phase of the cell cycle. [2] In mouse embryo, inhibition of Aurora kinase activity by ZM-447439 results in abnormalities during mitosis by regulating the phosphorylation of histone H3 serine 10 (H3S10Ph) from G2 to metaphase with different perturbations in each embryonic cycle. [3] A recent study shows that ZM-447439 exhibits growth inhibitory and proapoptotic effect on cervical cancer SiHa cells, and enhances the chemosensitivity to cisplatin.
in vivo:
 

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 513.59 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C29H31N5O4
CAS No 331771-20-1
Solvent & Solubility

DMSO ≥100mg/mL Water <1.2mg/mL Ethanol ≥45mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.9471 mL 9.7354 mL 19.4708 mL
5 mM 0.3894 mL 1.9471 mL 3.8942 mL
10 mM 0.1947 mL 0.9735 mL 1.9471 mL

References on ZM-447439

Inhibitor Kit

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