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  3. Biosimilar Antibodies
  4. Monoclonal Antibodies
  5. Zolbetuximab

Zolbetuximab  (Synonyms: IMAB362; Claudiximab; GC-182)

Cat. No.: HY-P99058 Purity: 98.03%
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SDS
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Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors.

For research use only. We do not sell to patients.

CAS No. : 1496553-00-4

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Customer Review

Based on 4 publication(s) in Google Scholar

Zolbetuximab Featured Recommendations:

Zolbetuximab Related Antibodies

Top Publications Citing Use of Products

    Zolbetuximab purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Aug 21;44(9):116191.  [Abstract]

    Zolbetuximab (0.01-100 nM). Dose-response curves of PDAC organoids in cell surface target-specific cytoablation assay. Data are representative of three biological replicates and are shown as mean ± SD.

    Zolbetuximab purchased from MedChemExpress. Usage Cited in: Heliyon. 2024 Jul 14;10(14):e34611.

    The titration of varying concentrations of CLDN 18.2 protein versus a fixed high concentration of Zolbetuximab (ZOL, 2 μg/mL).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors[1].

    Isotype

    Human IgG1 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    CLDN18.2
    In Vitro

    Zolbetuximab (0-100 μg/mL) binds to CLDN18.2+ PC cells, and induces antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Zolbetuximab Related Antibodies
    In Vivo

    Zolbetuximab (200 μg, i.v.) alone and in combination with Gemcitabine (HY-17026) (50 mg/kg, i.p.) exhibits antitumor activity in mouse BxPC-3-CLDN18.2 xenograft models[2].
    Zolbetuximab (5.7 mg/kg, i.p., three times per week for five weeks) inhibits tumor growth in SNU-620 cells xenograft model[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: mouse BxPC-3-CLDN18.2, MIA PaCa-2-CLDN18.2 xenograft model[2]
    Dosage: 200 μg alone or with 50 mg/kg Gemcitabine
    Administration: i.v.; i.p. (Gemcitabine)
    Result: Inhibited tumor growth in two models, and prevented lung metastasis formation.
    Prolonged survival time, and lowered fractions of CLDN18.2+ cells in MIA PaCa-2-CLDN18.2 xenograft.
    Clinical Trial
    Gene ID

    51208  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    147.09 kDa

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Zolbetuximab]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 kappa
    Biological Activity
    • Immobilized Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, HY-P78368) can bind Zolbetuximab. The EC50 for this effect is 6.588 ng/mL.
    Purity & Documentation

    Purity: 98.03%

    SDS (252 KB)

    COA (232 KB) SDS-PAGE (67 KB) SEC-HPLC (123 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    • If you have published this work, please enter the PubMed ID.
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    Zolbetuximab Related Classifications

    • Molarity Calculator

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Zolbetuximab1496553-00-4IMAB362 Claudiximab GC-182IMAB 362IMAB-362GC182GC 182GC-182OthersClaudin-18.2gastrointestinal adenocarcinomaspancreatic tumorsInhibitorinhibitorinhibit

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