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Signaling Pathway

AG-1478

HY-13524

(Tyrphostin AG-1478; AG 1478; NSC 693255; AG1478)

AG-1478

AG-1478 Chemical Structure

AG-1478 (NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM; almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.

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Free sample   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $70 In-stock
50 mg $250 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
5 mg €49 In-stock
10 mg €69 In-stock
50 mg €245 In-stock
100 mg Get quote
200 mg Get quote

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Product name: AG-1478
Cat. No.: HY-13524

AG-1478 Data Sheet

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    DataSheet

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Biological Activity of AG-1478

AG-1478 (NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM; almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
IC50 Value: 3 nM [1]
Target: EGFR
in vitro: AG1478 inhibited EGFR phosphorylation in CNE2 cells without reduced expression of EGFR protein. The activation of Akt and MAPK which are downstream molecules of EGFR signaling pathway, were also inhibited by AG1478 [2]. Although AG 1478 inhibited cell growth, DNA synthesis, EGFR tyrosine kinase activity, and receptor autophosphorylation of each cell line in a dose-dependent manner, it was significantly more potent in U87MG. delta EGFR cells than in the other two cell lines [3].
in vivo: At the lowest dose, plasma drug levels after the cessation of infusion declined with a half-life of approximately 43 min. EGFR activity, measured both by autophosphorylation and downstream signalling, was inhibited in a dose-dependent manner by injection of AG1478 in mice bearing xenografts of the human glioblastoma cell line U87MG [4].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 315.75 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C16H14ClN3O2
CAS No 153436-53-4
Solvent & Solubility

DMSO 25 mg/mL; Water <1 mg/mL; Ethanol 13 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.1671 mL 15.8353 mL 31.6706 mL
5 mM 0.6334 mL 3.1671 mL 6.3341 mL
10 mM 0.3167 mL 1.5835 mL 3.1671 mL

References on AG-1478

Inhibitor Kit

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