2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Flanvotumab

Flanvotumab  (Synonyms: IMC-20D7S)

Art. -Nr.: HY-P99622 Reinheit: ≥99.0%
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Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance.

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CAS. Nr. : 1188277-05-5

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Flanvotumab Related Antibodies

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Beschreibung

Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

TRP1/TYRP1
In Vitro

Flanvotumab is based on TA99, a murine IgG2a anti-TYRP1 mAb, localizes to subcutaneous melanoma xenografts and inhibits syngeneic tumor growth in preclinical models[1].
TA99 exhibits antitumor effect depending on the intact antibody, the presence of Fc receptor, and natural killer (NK) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flanvotumab Related Antibodies
Klinische Studie
Gene ID

7220  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

145.5 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Flanvotumab]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human TYRP1 Protein (His Tag) can bind Flanvotumab. The EC50 for this effect is 1.674 ng/mL.
Reinheit & Dokumentation
Verweise
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Flanvotumab Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flanvotumab1188277-05-5IMC-20D7STyrosinaseInhibitorinhibitorinhibit

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