1. GPCR/G Protein
  2. mGluR

LY341495 (Synonyms: LY 341495; LY-341495)

Cat. No.: HY-70059
Handling Instructions

LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.

For research use only. We do not sell to patients.
LY341495 Chemical Structure

LY341495 Chemical Structure

CAS No. : 201943-63-7

Size Price Stock Quantity
2 mg $50 In-stock
5 mg $90 Backordered
10 mg $132 Backordered
50 mg $530 Backordered
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200 mg   Get quote  

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Top Publications Citing Use of Products

    LY341495 purchased from MCE. Usage Cited in: Pain. 2016 Aug;157(8):1711-23.

    LY341495 and Sulfasalazine mildly suppress the effects of chronic constrictive injury (CCI)-induced mechanical allodynia and matrix metalloproteinase-9 activity by N-acetyl-cysteine (NAC).
    • Biological Activity

    • Protocol

    • Technical Information

    • References


    LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.

    IC50 & Target

    IC50: 2.9 nM (mGluR-2, human), 10 nM (mGluR-3, human), 170 nM (mGluR-8, human)

    In Vivo

    LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats[1]. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268[2]. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice[3]

    Preparing Stock Solutions
    Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
    1 mM 2.8299 mL 14.1495 mL 28.2990 mL
    5 mM 0.5660 mL 2.8299 mL 5.6598 mL
    10 mM 0.2830 mL 1.4149 mL 2.8299 mL
    Animal Administration

    LY341495 is dissolved in 0.1mol/LNaOH to a final volume of 5 mL, with saline (0.9% NaCl) solution.

    The rats are randomLy divided into six experimental groups (10 rats per group): vehicle and 0.05, 0.1, 0.3, 1, and 3 mg/kg LY341495. The LY341495 doses are selected on the basis of results from previous Published studies that evaluated the effects of this compound on cognition. The rats are subjected to a training session that consisted of two 2-min trials. The animals receive either vehicle or LY341495 immediately after T1. Using the 2-min trial duration, an ITI of 1 h is used because recognition memory is still intact in untreated control rats under these experimental conditions 





    CAS No.


    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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