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Products are for research use only. Not for human use. We do not sell to patients.
(BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032)
SNS-032 Chemical Structure
|Product name: SNS-032|
|Cat. No.: HY-10008|
SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
IC50 Value: 38 nM(for CDK2); 62 nM(for CDK7); 4 nM(for CDK9)
in vitro: BMS-387032 displays no activity against 190 additional kinases (IC50 >1000 nM). BMS-387032 arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. BMS-387032 prevents tumor cell-induced VEGF secretion and in vitro angiogenesis. SNS-032 inhibits three dimensional capillary network formations of endothelial cells. SNS-032 completely prevents U87MG cell–mediated capillary formation of HUVECs. In addition, SNS-032 significantly prevents the production of VEGF in both cell lines, SNS-032 prevents in vitro angiogenesis, and this action is attributable to blocking of VEGF. Preclinical studies have shown that SNS-032 induces cell cycle arrest and apoptosis across multiple cell lines.
in vivo: SNS-032 prevents tumor cell-induced VEGF secretion in a tumor coculture model. SNS-032, a new CDK inhibitor, is more selective and less cytotoxic and has been shown to prolong stable disease in solid tumors.
|M.Wt||380.53||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO ≥73mg/mL Water <1.2mg/mL Ethanol ≥73mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.6279 mL||13.1396 mL||26.2791 mL|
|5 mM||0.5256 mL||2.6279 mL||5.2558 mL|
|10 mM||0.2628 mL||1.3140 mL||2.6279 mL|
. Heath EI, Bible K, Martell RE, Adelman DC, Lorusso PM.A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors.Invest New Drugs. 2008 Feb;26(1):59-65. Epub 2007 Oct 16.
. Wu Y, Chen C, Sun X, Shi X, Jin B, Ding K, Yeung SC, Pan J.Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.Clin Cancer Res. 2012 Apr 1;18(7):1966-78. Epub 2012 Mar 23.
. Walsby E, Lazenby M, Pepper C, Burnett AK.The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine.Leukemia. 2011 Mar;25(3):411-9. Epub 2011 Jan 7.
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