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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

SNS-032

HY-10008

(BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032)

SNS-032

SNS-032 Chemical Structure

SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).

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Free sample   Apply now  
10 mM * 1 mL in DMSO $95 In-stock
5 mg $86 In-stock
10 mg $126 In-stock
50 mg $459 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €93 In-stock
5 mg €84 In-stock
10 mg €123 In-stock
50 mg €450 In-stock
100 mg Get quote
200 mg Get quote

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Product name: SNS-032
Cat. No.: HY-10008

SNS-032 Data Sheet

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    Purity: 98.62%

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Biological Activity of SNS-032

SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
IC50 Value: 38 nM(for CDK2); 62 nM(for CDK7); 4 nM(for CDK9)
Target: CDK
in vitro: BMS-387032 displays no activity against 190 additional kinases (IC50 >1000 nM). BMS-387032 arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. BMS-387032 prevents tumor cell-induced VEGF secretion and in vitro angiogenesis. SNS-032 inhibits three dimensional capillary network formations of endothelial cells. SNS-032 completely prevents U87MG cell–mediated capillary formation of HUVECs. In addition, SNS-032 significantly prevents the production of VEGF in both cell lines, SNS-032 prevents in vitro angiogenesis, and this action is attributable to blocking of VEGF. Preclinical studies have shown that SNS-032 induces cell cycle arrest and apoptosis across multiple cell lines.
in vivo: SNS-032 prevents tumor cell-induced VEGF secretion in a tumor coculture model. SNS-032, a new CDK inhibitor, is more selective and less cytotoxic and has been shown to prolong stable disease in solid tumors.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 380.53 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C17H24N4O2S2
CAS No 345627-80-7
Solvent & Solubility

DMSO ≥73mg/mL Water <1.2mg/mL Ethanol ≥73mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.6279 mL 13.1396 mL 26.2791 mL
5 mM 0.5256 mL 2.6279 mL 5.2558 mL
10 mM 0.2628 mL 1.3140 mL 2.6279 mL

References on SNS-032

Inhibitor Kit

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