2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK14 Isoform

CDK14

CDK14, also named PFTAIREI, is a CDC2-associated serine/threonine protein kinase and can act as an essential regulator of CCNs and cell cycle development. Interestingly, CDK14 can regulate cell cycle progression and cell proliferation by interacting with CCNY that is the regulatory submit of CDK14 and promotes Wnt signaling by mediating cell cycle-dependent low-density-lipoprotein receptor-related protein 6 (LRP6) phosphorylation which is a key regulatory nexus in Wnt/β-catenin pathway.

CDK14 Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-127104
    FMF-04-159-2
    		Inhibitor 98.92%
    FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively.
  • HY-160213
    JA397
    		Inhibitor
    JA397 is a potent and selective inhibitor for the TAIRE family with cellular activity ranging from IC50 values of 21 nM to 307 nM.