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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

U0126

HY-12031

(U0126-EtOH; U 0126; U-0126)

U0126

U0126 Chemical Structure

U0126-EtOH(U-0126) is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059.

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10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $88 In-stock
100 mg $110 In-stock
200 mg $150 In-stock
500 mg $266 In-stock
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Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
10 mg €49 In-stock
50 mg €86 In-stock
100 mg €108 In-stock
200 mg €147 In-stock
500 mg €261 In-stock
1 g Get quote
5 g Get quote

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Product name: U0126
Cat. No.: HY-12031

U0126 Data Sheet

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    Purity: >98.0%

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Biological Activity of U0126

U0126-EtOH(U-0126) is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059.
IC50 value: 70/60 nM(MEK1/2) [1]
Target: MEK1/2
in vitro: U0126-EtOH functionally antagonizes AP- 1 transcriptional activity and blocks the production of a variety of cytokines and metalloproteinases involved in the inflammatory response. [1] U0126-EtOH inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs without effect on IL-2-induced proliferation by down-regulating IL-2 mRNA levels [2]. A recent study shows that U0126-EtOH antagonizes resveratrol-induced apoptosis in castration-resistant human prostate cancer C4-2 cells, inhibits mitochondrial function and shifts cells to aerobic glycolysis independently of MEK [3].
in vivo: U0126-EtOH, as the inhibitor of intracellular Raf/MEK/ERK signaling pathway, demonstrates antiviral activity by suppressing propagation of the 2009 pandemic IV H1N1 variant and highly pathogenic avian influenza viruses (HPAIV) in vivo in the mouse lung by inhibiting [4].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 426.56 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C20H22N6OS2
CAS No 1173097-76-1
Solvent & Solubility

DMSO ≥ 10mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.3443 mL 11.7217 mL 23.4434 mL
5 mM 0.4689 mL 2.3443 mL 4.6887 mL
10 mM 0.2344 mL 1.1722 mL 2.3443 mL

References on U0126

Inhibitor Kit

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