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Signaling Pathway

1-NM-PP1

HY-13942

(PP1 Analog II; 1-NM-PP 1)

1-NM-PP1

1-NM-PP1 Chemical Structure

1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G).

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10 mM * 1 mL in DMSO $105 In-stock
5 mg $95 In-stock
10 mg $150 In-stock
50 mg $580 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €103 In-stock
5 mg €93 In-stock
10 mg €147 In-stock
50 mg €568 In-stock
100 mg Get quote
200 mg Get quote

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Product name: 1-NM-PP1
Cat. No.: HY-13942

1-NM-PP1 Data Sheet

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    Purity: 98.02%

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Biological Activity of 1-NM-PP1

1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G).
IC50 Value: 4.2 nM (v-Src-as1 I338G) [1]
Target: Src Family Kinase
PP1 Analog II, 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. 1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive', as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for CDK2-as1 versus 29 μM for CDK2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems. In addition it has been shown to activate mutants of Ire1, a transmembrane kinase.
 

Chemical Information

M.Wt 331.41 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C20H21N5
CAS No 221244-14-0
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.0174 mL 15.0871 mL 30.1741 mL
5 mM 0.6035 mL 3.0174 mL 6.0348 mL
10 mM 0.3017 mL 1.5087 mL 3.0174 mL

References on 1-NM-PP1

Inhibitor Kit

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