2. PI3K/Akt/mTOR
  3. Akt mTOR
  4. 22-(4′-py)-JA

22-(4′-py)-JA  (Synonyms: 22-(4′-Pyridinecarbonyl) jorunnamycin A)

Cat. No.: HY-155721
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22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

22-(4′-py)-JA Chemical Structure

22-(4′-py)-JA Chemical Structure

CAS No. : 1178895-15-2

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22-(4′-py)-JA Related Antibodies

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Description

22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC)[1].

In Vivo

22-(4′-py)-JA

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

598.60

Formula

C32H30N4O8
CAS No.
SMILES

O=C(C1=C(C2=O)C[C@@]3([H])[C@H](C#N)N4[C@@H](COC(C5=CC=NC=C5)=O)C(C(C(OC)=C(C)C6=O)=O)=C6C[C@@]4([H])[C@@]([H])1N3C)C(OC)=C2C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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22-(4′-py)-JA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

22-(4′-py)-JA1178895-15-222-(4′-Pyridinecarbonyl) jorunnamycin AAktmTORPKBProtein kinase BMammalian target of Rapamycinnon-small cell lung cancerantimetastaticjunamycin A derivativeInhibitorinhibitorinhibit

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