2. Others Metabolic Enzyme/Protease Cytoskeleton Cell Cycle/DNA Damage NF-κB Vitamin D Related/Nuclear Receptor
  3. Isotope-Labeled Compounds PAK NF-κB PPAR Endogenous Metabolite
  4. 5-Aminosalicylic acid-d3

5-Aminosalicylic acid-d3  (Synonyms: Mesalamine-d3; 5-ASA-d3; Mesalazine-d3)

Cat. No.: HY-15027S1 Purity: 99.38%
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5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

For research use only. We do not sell to patients.

5-Aminosalicylic acid-d<sub>3</sub> Chemical Structure

5-Aminosalicylic acid-d3 Chemical Structure

CAS No. : 1309283-32-6

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Aminosalicylic acid-d3:

5-Aminosalicylic acid-d3 Related Antibodies

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Description

5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Aminosalicylic acid-d3 Related Antibodies
Molecular Weight

156.15

Formula

C7H4D3NO3
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

OC(C1=C(C([2H])=C([2H])C(N)=C1[2H])O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (426.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4041 mL 32.0205 mL 64.0410 mL
5 mM 1.2808 mL 6.4041 mL 12.8082 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.4041 mL 32.0205 mL 64.0410 mL 160.1025 mL
5 mM 1.2808 mL 6.4041 mL 12.8082 mL 32.0205 mL
10 mM 0.6404 mL 3.2020 mL 6.4041 mL 16.0102 mL
15 mM 0.4269 mL 2.1347 mL 4.2694 mL 10.6735 mL
20 mM 0.3202 mL 1.6010 mL 3.2020 mL 8.0051 mL
25 mM 0.2562 mL 1.2808 mL 2.5616 mL 6.4041 mL
30 mM 0.2135 mL 1.0673 mL 2.1347 mL 5.3367 mL
40 mM 0.1601 mL 0.8005 mL 1.6010 mL 4.0026 mL
50 mM 0.1281 mL 0.6404 mL 1.2808 mL 3.2020 mL
60 mM 0.1067 mL 0.5337 mL 1.0673 mL 2.6684 mL
80 mM 0.0801 mL 0.4003 mL 0.8005 mL 2.0013 mL
100 mM 0.0640 mL 0.3202 mL 0.6404 mL 1.6010 mL
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5-Aminosalicylic acid-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Aminosalicylic acid-d31309283-32-6Mesalamine-d35-ASA-d3Mesalazine-d3Isotope-Labeled CompoundsPAKNF-κBPPAREndogenous Metabolitep21 activated kinasesNuclear factor-κBNuclear factor-kappaBPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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