Benzcyclane (Synonyms: Bencyclane; Benzcyclan)

Cat. No.: HY-U00134 Purity: 98.51%: FAQs
Data Sheet SDS COA Handling Instructions

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Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.

For research use only. We do not sell to patients.

Benzcyclane Chemical Structure

CAS No. : 2179-37-5

Size	Price	Stock	Quantity
1 mg	USD 382	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Purity & Documentation
References
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Description

Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.

In Vivo

Benzcyclane, although capable of aggregating platelets by itself at very high concentrations, shows a striking inhibitory effect, over a wide range of concentrations, both on platelet aggregation induced by ADP, epinephrine or collagen and on platelet adhesiveness to glass or collagen. Clot retraction is also clearly inhibited^[1]. Benzcyclane induces use-dependent inhibition of Na channels in muscle, similarly as do class 1 antiarrhytnmic drugs. Inhibition was observed with both normal and cevadine-modified Na channels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

289.46

Formula

C₁₉H₃₁NO

CAS No.

2179-37-5

Appearance

Oil

Color

Colorless to light yellow

SMILES

CN(C)CCCOC1(CC2=CC=CC=C2)CCCCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (345.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4547 mL	17.2735 mL	34.5471 mL
5 mM	0.6909 mL	3.4547 mL	6.9094 mL
10 mM	0.3455 mL	1.7274 mL	3.4547 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.39%

Select Batch:

Data Sheet (272 KB) SDS (0 KB)

COA (248 KB) HNMR (140 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. Ponari O, et al. In vitro effects of bencyclan on coagulation, fibrinolysis and platelet function. Arzneimittelforschung. 1976;26(8):1532-8. [Content Brief]

[2]. Nánási PP, et al. Effects of bencyclane on normal and cevadine-modified Na channels in frog skeletal muscle. Gen Physiol Biophys. 1989 Oct;8(5):447-58. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4547 mL	17.2735 mL	34.5471 mL	86.3677 mL
	5 mM	0.6909 mL	3.4547 mL	6.9094 mL	17.2735 mL
	10 mM	0.3455 mL	1.7274 mL	3.4547 mL	8.6368 mL
	15 mM	0.2303 mL	1.1516 mL	2.3031 mL	5.7578 mL
	20 mM	0.1727 mL	0.8637 mL	1.7274 mL	4.3184 mL
	25 mM	0.1382 mL	0.6909 mL	1.3819 mL	3.4547 mL
	30 mM	0.1152 mL	0.5758 mL	1.1516 mL	2.8789 mL
	40 mM	0.0864 mL	0.4318 mL	0.8637 mL	2.1592 mL
	50 mM	0.0691 mL	0.3455 mL	0.6909 mL	1.7274 mL
	60 mM	0.0576 mL	0.2879 mL	0.5758 mL	1.4395 mL
	80 mM	0.0432 mL	0.2159 mL	0.4318 mL	1.0796 mL
	100 mM	0.0345 mL	0.1727 mL	0.3455 mL	0.8637 mL

Benzcyclane Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzcyclane2179-37-5Bencyclane BenzcyclanOthersInhibitorinhibitorinhibit

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