1. MAPK/ERK Pathway
  2. JNK

D-JNKI-1 (Synonyms: AM-111; XG-102)

Cat. No.: HY-P0069
Handling Instructions

D-JNKI-1 is a specific inhibitor of JNK, and strongly interferes with JNK activation.

For research use only. We do not sell to patients.
D-JNKI-1 Chemical Structure

D-JNKI-1 Chemical Structure

Size Price Stock Quantity
1 mg $150 In-stock
5 mg $300 In-stock
10 mg $450 In-stock
50 mg $1150 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

D-JNKI-1 is a specific inhibitor of JNK, and strongly interferes with JNK activation.

In Vitro

D-JNKI-1 (1 μM-1 mM) treatment prevents apoptosis and loss of neomycin-exposed hair cells[1].

In Vivo

D-JNKI-1 (10 μM) prevents nearly all hair cell death and permanent hearing loss induced by neomycin ototoxicity in the scala tympani of the guinea pig cochlea. Local delivery of D-JNKI-1 also prevents acoustic trauma-induced permanent hearing loss in a dose-dependent manner[1]. D-JNKI-1 (0.3 mg/kg, i.p.) reverses these pathological events in the brain mitochondria of the rat and almost completely abolishes cytochrome c release and PARP cleavage[2]. D-JNKI-1 (1 μg/kg, s.c.) results in a significant decrease in the disease activity index, and reduces the expression of CD4+ and CD8+ cells in mice[3].

Clinical Trial
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References
Animal Administration
[3]

D-JNKI-1 is dissolved in a 0.9% sodium chloride solution.

D-JNKI-1 is dissolved in a 0.9% sodium chloride solution for subcutaneous application. Each group (the 1.0% DSS group and the 1.5% DSS group) is randomly subdivided into an intervention group (n = 15) and a control group (n = 15). The mice in the intervention group receive three subcutaneous nuchal administrations of 1 μg/kg D-JNKI-1 on days 2, 12, and 22. The mice in the control group receive physiological saline subcutaneously as a negative control at the same time points in a comparable stress situation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 50 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
D-JNKI-1
Cat. No.:
HY-P0069
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