2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Fmoc-Phe-Lys(Boc)-PAB-PNP

Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Phe-Lys(Boc)-PAB-PNP Chemical Structure

Fmoc-Phe-Lys(Boc)-PAB-PNP Chemical Structure

CAS No. : 1646299-50-4

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Based on 1 publication(s) in Google Scholar

Fmoc-Phe-Lys(Boc)-PAB-PNP Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fmoc-Phe-Lys(Boc)-PAB-PNP

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Description

Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Protease Cleavable Linker

 

Cleavable Linker

 

Molecular Weight

885.96

Formula

C49H51N5O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1=CC=C([N+]([O-])=O)C=C1)OCC(C=C2)=CC=C2NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@H](CC3=CC=CC=C3)NC(OCC4C5=CC=CC=C5C6=CC=CC=C46)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (6.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1287 mL 5.6436 mL 11.2872 mL
5 mM 0.2257 mL 1.1287 mL 2.2574 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1287 mL 5.6436 mL 11.2872 mL 28.2180 mL
5 mM 0.2257 mL 1.1287 mL 2.2574 mL 5.6436 mL
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Fmoc-Phe-Lys(Boc)-PAB-PNP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Phe-Lys(Boc)-PAB-PNP1646299-50-4ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Fmoc-Phe-Lys(Boc)-PAB-PNP
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