1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Kinesin

K858 

Cat. No.: HY-19966
Handling Instructions

K858 selectively inhibits Eg5 ATPase activity with an IC50 of 1.3 μM.

For research use only. We do not sell to patients.
K858 Chemical Structure

K858 Chemical Structure

CAS No. : 72926-24-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $120 In-stock
50 mg $450 In-stock
100 mg $650 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

K858 selectively inhibits Eg5 ATPase activity with an IC50 of 1.3 μM. IC50 value: 1.3 μM [1] Target: Eg5 ATPase in vitro: K858 is an ATP-uncompetitive inhibitor of Eg5 that is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 induces mitotic arrest and growth inhibition through the activation of the Mad2-mediated spindle checkpoint. K858 induces mitotic cell death in cancer cells but not in normal cells. K858 induces mitotic arrest, apoptosis, and cell growth inhibition and has no effect on microtubule polymerization. [1] in vivo: K858 exhibits antitumor activity and induces mitotic arrest in a human tumor xenograft mouse model. K858 exhibits antitumor activity and induces mitotic arrest in human xenograft tumor models. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.6057 mL 18.0284 mL 36.0568 mL
5 mM 0.7211 mL 3.6057 mL 7.2114 mL
10 mM 0.3606 mL 1.8028 mL 3.6057 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

277.34

Formula

C₁₃H₁₅N₃O₂S

CAS No.

72926-24-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
K858
Cat. No.:
HY-19966
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