1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease

Ombitasvir (Synonyms: ABT-267)

Cat. No.: HY-13997 Purity: 99.89%
Data Sheet SDS Handling Instructions

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.

For research use only. We do not sell to patients.
Ombitasvir Chemical Structure

Ombitasvir Chemical Structure

CAS No. : 1258226-87-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO $492 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
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500 mg   Get quote  

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Description

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.

IC50 & Target

EC50: 0.82 to 19.3 pM (HCV genotypes 1 to 5), 366 pM (HCV genotype 6a)[1]

In Vitro

Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively[1]. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir[2].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01704755 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection|Compensated Cirrhosis October 2012 Phase 3
NCT01911845 AbbVie Chronic Hepatitis C Infection|Chronic Hepatitis C April 2013 Phase 2
NCT01674725 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection August 2012 Phase 3
NCT02534870 AbbVie Healthy Volunteer September 2015 Phase 1
NCT01672983 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection July 2012 Phase 2
NCT02023112 AbbVie Hepatitis C Virus January 2014 Phase 3
NCT01314261 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C|Hepatitis C Virus (HCV) Infection March 2011 Phase 2
NCT02052362 AbbVie Absolute Bioavailability January 2014 Phase 1
NCT01563536 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection February 2012 Phase 2
NCT02517528 AbbVie Chronic Hepatitis C Virus July 2015 Phase 3
NCT01685203 AbbVie (prior sponsor, Abbott)|AbbVie Hepatitis C, Chronic August 2012 Phase 2
NCT02167945 AbbVie Chronic Hepatitis C Virus (HCV) Infection Genotype 1 June 12, 2014 Phase 3
NCT02219490 AbbVie Chronic Hepatitis C Virus (HCV) Infection Genotype 1 October 30, 2014 Phase 3
NCT02517515 AbbVie Chronic Hepatitis C Virus July 16, 2015 Phase 3
NCT01767116 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection December 2012 Phase 3
NCT02023099 AbbVie Chronic Hepatitis C Infection December 2013 Phase 3
NCT01833533 AbbVie Chronic Hepatitis C Infection March 2013 Phase 3
NCT01716585 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection November 2012 Phase 3
NCT01715415 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection November 2012 Phase 3
NCT01181427 Abbott HCV Infection August 2010 Phase 1
NCT01458535 AbbVie (prior sponsor, Abbott)|AbbVie Hepatitis C Virus September 2011 Phase 2
NCT01464827 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C|Hepatitis C (HCV)|Hepatitis C Genotype 1 October 2011 Phase 2
NCT01939197 AbbVie Hepatitis C Virus Infection|Human Immunodeficiency Virus Infection|Chronic Hepatitis C|Compensated Cirrhosis and Non-cirrhotics August 2013 Phase 3
NCT01854528 AbbVie Chronic Hepatitis C Infection June 2013 Phase 3
NCT01854697 AbbVie Chronic Hepatitis C Infection March 2013 Phase 3
NCT01782495 AbbVie Chronic Hepatitis C Infection February 25, 2013 Phase 2
NCT01609933 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C|Hepatitis C (HCV)|Hepatitis C Genotype 1 December 18, 2012 Phase 2
NCT01773070 AbbVie (prior sponsor, Abbott)|AbbVie Hepatitis C June 2013 Phase 3
NCT01995071 AbbVie Chronic Hepatitis C|Hepatitis C Virus|Compensated Cirrhosis November 2013 Phase 2
NCT02734173 Ottawa Hospital Research Institute|AbbVie Hepatitis C July 2015 Phase 4
NCT01704755 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection|Compensated Cirrhosis October 2012 Phase 3
NCT01911845 AbbVie Chronic Hepatitis C Infection|Chronic Hepatitis C April 2013 Phase 2
NCT01674725 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection August 2012 Phase 3
NCT02534870 AbbVie Healthy Volunteer September 2015 Phase 1
NCT01672983 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection July 2012 Phase 2
NCT02023112 AbbVie Hepatitis C Virus January 2014 Phase 3
NCT01314261 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C|Hepatitis C Virus (HCV) Infection March 2011 Phase 2
NCT02052362 AbbVie Absolute Bioavailability January 2014 Phase 1
NCT01563536 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection February 2012 Phase 2
NCT02517528 AbbVie Chronic Hepatitis C Virus July 2015 Phase 3
NCT01685203 AbbVie (prior sponsor, Abbott)|AbbVie Hepatitis C, Chronic August 2012 Phase 2
NCT02167945 AbbVie Chronic Hepatitis C Virus (HCV) Infection Genotype 1 June 12, 2014 Phase 3
NCT02219490 AbbVie Chronic Hepatitis C Virus (HCV) Infection Genotype 1 October 30, 2014 Phase 3
NCT02517515 AbbVie Chronic Hepatitis C Virus July 16, 2015 Phase 3
NCT01767116 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection December 2012 Phase 3
NCT02023099 AbbVie Chronic Hepatitis C Infection December 2013 Phase 3
NCT01833533 AbbVie Chronic Hepatitis C Infection March 2013 Phase 3
NCT01716585 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection November 2012 Phase 3
NCT01715415 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C Infection November 2012 Phase 3
NCT01181427 Abbott HCV Infection August 2010 Phase 1
NCT01458535 AbbVie (prior sponsor, Abbott)|AbbVie Hepatitis C Virus September 2011 Phase 2
NCT01464827 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C|Hepatitis C (HCV)|Hepatitis C Genotype 1 October 2011 Phase 2
NCT01939197 AbbVie Hepatitis C Virus Infection|Human Immunodeficiency Virus Infection|Chronic Hepatitis C|Compensated Cirrhosis and Non-cirrhotics August 2013 Phase 3
NCT01854528 AbbVie Chronic Hepatitis C Infection June 2013 Phase 3
NCT01854697 AbbVie Chronic Hepatitis C Infection March 2013 Phase 3
NCT01782495 AbbVie Chronic Hepatitis C Infection February 25, 2013 Phase 2
NCT01609933 AbbVie (prior sponsor, Abbott)|AbbVie Chronic Hepatitis C|Hepatitis C (HCV)|Hepatitis C Genotype 1 December 18, 2012 Phase 2
NCT01773070 AbbVie (prior sponsor, Abbott)|AbbVie Hepatitis C June 2013 Phase 3
NCT01995071 AbbVie Chronic Hepatitis C|Hepatitis C Virus|Compensated Cirrhosis November 2013 Phase 2
NCT02734173 Ottawa Hospital Research Institute|AbbVie Hepatitis C July 2015 Phase 4
NCT02219503 AbbVie Chronic Hepatitis C Infection|Compensated Cirrhosis September 2014 Phase 3
NCT02609659 AbbVie Chronic Hepatitis C Infection October 2015 Phase 3
NCT02582632 AbbVie Hepatitis C Infection|Hepatitis C Virus November 2015 Phase 3
NCT03122132 Hepa C Hepatitis C Infection February 20, 2017
NCT02399345 AbbVie Chronic Hepatitis C Virus (HCV Infection Genotype 1) March 2015 Phase 3
NCT02806362 AbbVie Chronic Hepatitis C Virus September 2016 Phase 3
NCT02504099 AbbVie Chronic Hepatitis C Infection July 2015 Phase 3
NCT02476617 AbbVie Chronic Hepatitis C|Hepatitis C (HCV)|Hepatitis C Genotype 1a June 2015 Phase 3
NCT02493855 AbbVie Chronic Hepatitis C|Hepatitis C (HCV)|Hepatitis C Genotype 1a June 2015 Phase 2
NCT02219477 AbbVie Chronic Hepatitis C|Decompensated Cirrhosis|Hepatitis C Virus November 24, 2014 Phase 3
NCT02356562 AbbVie Chronic Hepatitis C Infection February 3, 2015 Phase 2
NCT02207088 AbbVie Chronic Hepatitis C|Hepatitis C Virus|Compensated Cirrhosis|Severe Renal Impairment|End-stage Renal Disease September 2014 Phase 3
NCT02292719 AbbVie Chronic Hepatitis C Virus Infection December 19, 2014 Phase 2
NCT02216422 AbbVie Chronic Hepatitis C Virus (HCV) Infection September 2014 Phase 3
NCT02487199 AbbVie HCV|Genotype 1a|Genotype 4|Chronic Kidney Disease|Hepatitis C|pegIFN|IFN September 2015 Phase 3
NCT03067883 Ain Shams University Chronic Hepatitis c November 9, 2016 Phase 2
NCT02442284 AbbVie Chronic Hepatitis C|Cirrhosis|Hepatitis C Virus May 2015 Phase 3
NCT02265237 AbbVie Hepatitis C Virus October 28, 2014 Phase 3
NCT02442271 AbbVie Chronic Hepatitis C Infection April 2015 Phase 3
NCT02950870 University of Modena and Reggio Emilia Chronic Hepatitis, C Virus December 2016 Phase 4
NCT02461745 Kaiser Permanente|AbbVie Hepatitis C, Chronic June 2015 Phase 4
NCT02634008 Kirby Institute|AbbVie Hepatitis C, Acute June 2016 Phase 3
NCT02486406 AbbVie Chronic Hepatitis C Infection October 28, 2015 Phase 3
NCT02786537 University of Florida|Patient-Centered Outcomes Research Institute|Merck Sharp & Dohme Corp.|AbbVie Chronic Hepatitis C June 2016 Phase 4
NCT02707952 AbbVie Chronic Hepatitis C Virus|Hepatitis C Virus February 2016 Phase 3
NCT02555943 Humanity & Healthy GI and Liver Centre|Beijing 302 Hospital|Nanfang Hospital of Southern Medical University Chronic Hepatitis C Infection|HBV Coinfection|Hepatitis B Reactivation February 2015 Phase 2|Phase 3
NCT02194998 National Institute of Allergy and Infectious Diseases (NIAID) HIV Infections August 2015 Phase 2
NCT02758509 Parc de Salut Mar Chronic Hepatitis C|Cirrhosis January 1, 2010
NCT02460133 Lisa Barrett|PEI Provincial Correction Centre|Nova Scotia Health Authority Hepatitis C Virus July 2015 Phase 4
NCT02333292 Valme University Hospital|Hospital del SAS de Jerez|Hospital General Universitario Elche|Hospital La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Hospital de Figueres|Hospital Universitario Puerto Real|Hospital Universitario Virgen de la Victoria|Hospital Universitario de Canarias|Hospital General Universitario de Alicante|Hospital Universitario Araba|Hospital Royo Vilanova|Hospital Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Hospital Universitario Reina Sofia|Hospital Universitario Virgen Macarena|Complexo Hospitalario Universitario de Vigo|Clinica Universidad de Navarra, Universidad de Navarra|Hospital Clinico Universitario San Cecilio|Hospital Universitario La Fe|Hospital General Universitario de Valencia|Hospital Universitario Infanta Leonor|Hospital Universitario de Gran Canaria|Hospital General Universitario Santa Lucía|Centro Penitenciario Alicante 1|Hospital Regional Universitario Carlos Haya|Hospital Virgen de la Luz|Hospital General Universitario de Castellón|Hospital Parc Taulí, Sabadell Chronic Hepatitis C Infection December 2014
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References
M.Wt

894.11

Formula

C₅₀H₆₇N₇O₈

CAS No.

1258226-87-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 33 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Ombitasvir
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