1. Metabolic Enzyme/Protease
    Anti-infection
  2. HCV
    HCV Protease

Ombitasvir (Synonyms: ABT-267; ABT267; ABT 267)

Cat. No.: HY-13997 Purity: 99.89%
Handling Instructions

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.

For research use only. We do not sell to patients.
Ombitasvir Chemical Structure

Ombitasvir Chemical Structure

CAS No. : 1258226-87-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO $492 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.

IC50 & Target

EC50: 0.82 to 19.3 pM (HCV genotypes 1 to 5), 366 pM (HCV genotype 6a)[1]

In Vitro

Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively[1]. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir[2].

Clinical Trial
Sponsor Condition Start Date Phase
AbbVie (prior sponsor, Abbott) Chronic Hepatitis C Infection Compensated Cirrhosis 2012-09-28 Phase 3
References
M.Wt

894.11

Formula

C₅₀H₆₇N₇O₈

CAS No.

1258226-87-7

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 33 mg/mL

Purity: 99.89%

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Product Name:
Ombitasvir
Cat. No.:
HY-13997
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