1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

Philanthotoxin 74 dihydrochloride (Synonyms: PhTx 74 dihydrochloride)

Cat. No.: HY-104020A
Handling Instructions

Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.

For research use only. We do not sell to patients.
Philanthotoxin 74 dihydrochloride Chemical Structure

Philanthotoxin 74 dihydrochloride Chemical Structure

CAS No. : 1227301-51-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO $89 In-stock
1 mg $50 In-stock
5 mg $80 In-stock
10 mg $120 In-stock
25 mg $280 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.

IC50 & Target

IC50: 296 nM (GluR1), 296 nM (GluR1)[1]

Ki: 0.29 μM (GluR5Q)[2]

In Vitro

Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2[1].

References
Molecular Weight

507.54

Formula

C₂₄H₄₄Cl₂N₄O₃

CAS No.

1227301-51-0

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Philanthotoxin 74 dihydrochloride
Cat. No.:
HY-104020A
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