1. Metabolic Enzyme/Protease
    Autophagy
  2. Phospholipase
    Autophagy

Quinacrine dihydrochloride (Synonyms: Mepacrine dihydrochloride; SN-390)

Cat. No.: HY-13735A Purity: 98.00%
Data Sheet SDS Handling Instructions

Quinacrine is a fluorescent probe for the conformational transitions of the cholinergic receptor protein.

For research use only. We do not sell to patients.
Quinacrine dihydrochloride Chemical Structure

Quinacrine dihydrochloride Chemical Structure

CAS No. : 69-05-6

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Quinacrine is a fluorescent probe for the conformational transitions of the cholinergic receptor protein. Quinacrine shows activity in the low μM range with a mean IC50 of 2.30 μM In the patient AML cells. IC50 value: 2.30 μM (for AML cells) Target: in vitro: Quinacrine is a fluorescent probe for the conformational transitions of the cholinergic receptor protein in its membrane-bound state.[1] In the patient AML samples, Quinacrine showed activity in the low μM range with a mean IC50 of 2.30 μM, statistically significantly lower than that of normal PBMCs; 3.54 μM (P=0.0327; Student's t-test). Samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) were tested in response to 1266 compounds from the LOPAC1280 library. 25 compounds were defined as hits with activity in all leukemia subgroups (<50% cell survival compared with control) at 10 μM drug concentration. Only Quinacrine showed concurrent high activity in all leukemia subgroups and low activity in normal PBMCs and was, therefore, selected for further preclinical evaluation. Quinacrine also induced early inhibition of both DNA and protein synthesis. Quinacrine have repositioning potential for treatment of acute myeloid leukemia by targeting of ribosomal biogenesis.[2]

Clinical Trial
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References
Molecular Weight

472.88

Formula

C₂₃H₃₂Cl₃N₃O

CAS No.

69-05-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 44 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Quinacrine dihydrochloride
Cat. No.:
HY-13735A
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