1. Cell Cycle/DNA Damage
  2. CRISPR/Cas9

RS-1 

Cat. No.: HY-19793 Purity: 99.42%
Handling Instructions

RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51.

For research use only. We do not sell to patients.
RS-1 Chemical Structure

RS-1 Chemical Structure

CAS No. : 312756-74-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 83 In-stock
5 mg USD 72 In-stock
10 mg USD 102 In-stock
50 mg USD 306 In-stock
100 mg USD 552 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. RS-1 increases CRISPR/Cas9-mediated editing frequency. In vitro: RS-1 can be used to kill human cancer cells, and that its toxicity is modulated by both RAD51 and RAD54 translocase expression levels. RS-1, increases the knock-in efficiency by two- to five-fold at different loci, whereas NHEJ inhibitor SCR7 has minimal effects. [1] Studies have shown that chitosan solutions at 0.10, 0.20, and 0.40 mg/mL inhibited the in vitro growth of Aaa strain RS-1. [3] In vivo: You can use RS-1 at 7.5μM for the in vivo experiments. RS-1 seems to function in vivo to stimulate homologous recombination repair proficiency. [2]

References
Molecular Weight

524.23

Formula

C₂₀H₁₆Br₂N₂O₃S

CAS No.

312756-74-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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RS-1
Cat. No.:
HY-19793
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