2. Signaling Pathways
  3. Apoptosis
  4. Caspase
  5. Caspase 1 Isoform
  6. Caspase 1 Activator

Caspase 1 Activator

Caspase 1 Activators (2):

Cat. No. Product Name Effect Purity
  • HY-115630
    cRIPGBM chloride
    		Activator 99.73%
    cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models.
  • HY-125466
    cRIPGBM
    		Activator
    cRIPGBM, a proapoptotic derivative of RIPGBM, a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to receptor-interacting protein kinase 2 (RIPK2), with an EC50 of 68 nM in GBM-1 cells.