Glucokinase Activator

Glucokinase Activators (21):

Cat. No.	Product Name	Effect	Purity

HY-109030

Dorzagliatin	Activator	99.87%
Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.

HY-N2341

Palmitelaidic Acid	Activator	≥99.0%
Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

HY-10595

RO-28-1675	Activator	99.95%
RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC₅₀ of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.

HY-15671

GKA50	Activator	99.57%
GKA50 is a potent glucokinase activator (EC₅₀=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca²⁺-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats.

HY-15675

AZD1656	Activator	98.02%
AZD1656 is a potent, selective and orally active glucokinase activator with an EC₅₀ of 60 nM. AZD1656 has the potential for type 2 diabetes research.

HY-116946

Glucokinase activator 6	Activator
Glucokinase activator 6 (compound 9) is a potent glucokinase activator, with an EC₅₀ of 0.09 μM. Glucokinase activator 6 can be used for type 2 diabetes (T2D) research.

HY-13529

Globalagliatin	Activator	≥98.0%
Globalagliatin (LY2608204) is a activator of glucokinase (GK) with EC50 of 42 nM.

HY-108328

Nerigliatin	Activator	99.78%
Nerigliatin (PF-04937319) is a glucokinase activator (GKA) with EC₅₀ value of 154.4 ?μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus. Nerigliatin is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs.

HY-133127

AR453588	Activator	99.84%
AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC₅₀ of 42 nM. AR453588 shows anti-hyperglycemic activity.

HY-100221

AM-2394	Activator	99.48%
AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC₅₀ of 60 nM.

HY-144287

Glucokinase activator 3	Activator	98.36%
Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC₅₀ of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes.

HY-144289

BMS-820132	Activator	99.39%
BMS-820132 is an orally active and partial glucokinase (GK) activator with a AC₅₀ of 29 nM. BMS-820132 decreases the glucose levels in glucose tolerance test (OGTT) model in normal rats, but not Zucker diabetic fatty (ZDF) rats. BMS-820132 exhibits pharmacological toxicity secondary to strong GK activation.

HY-15671A

GKA50 quarterhydrate	Activator	≥98.0%
GKA50 quarterhydrate is a potent glucokinase activator (EC₅₀=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca²⁺-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats.

HY-19843A

MK-0941 free base	Activator
MK-0941 free base is an orally active glucokinase activator, with EC₅₀s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.

HY-133127A

AR453588 hydrochloride	Activator
AR453588 hydrochloride is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC₅₀ of 42 nM. AR453588 hydrochloride shows anti-hyperglycemic activity.

HY-147254

Cadisegliatin	Activator	99.10%
Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes.

HY-101788

Glucokinase activator 1	Activator
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC₅₀ of 34 nM.

HY-N2341S

Palmitelaidic acid-d₁₃	Activator
Palmitelaidic acid-d₁₃ is the deuterium labeled Palmitelaidic Acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

HY-121070

AZD1092	Activator
AZD1092 is an orally active glucokinase (GK) activator with an EC₅₀ value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).

HY-116682

GKA-71	Activator
GKA-71 is an orally active Glucokinase activator, possesses an islet protective effect.

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