2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Hexokinase
  5. Hexokinase Degrader

Hexokinase Degrader

Hexokinase Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-155008
    PROTAC HK2 Degrader-1
    		Degrader 98.66%
    PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research.