1. PROTAC
  2. Ligand for E3 Ligase

Ligand for E3 Ligase

The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Ligand for E3 Ligase Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-100947
    VH-298
    VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology.
  • HY-103596
    E3 ligase Ligand 2
    E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.
  • HY-42424
    E3 ligase Ligand 1
    E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.
  • HY-41547
    E3 ligase Ligand 4
    E3 ligase Ligand 4 is a ligand of E3 ligase, used in PROTAC technology.
  • HY-103597
    E3 ligase Ligand 3
    E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.