2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel
  5. TRPML Isoform

TRPML

 

TRPML Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-134819A
    (1R,2R)-ML-SI3
    		Inhibitor 99.45%
    (1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.
  • HY-139426
    ML-SI3
    		Inhibitor
    ML-SI3 is a mixture of cis/trans ML-SI3. ML-SI3 is a TRPML channel modulator. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 µM and 1.7 µM, respectively. ML-SI3 is also able to activate TRPML2 and TRPML3 with EC50s of 3.3-9.4 μM and 29 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy.
  • HY-139426A
    (rel)-ML-SI3
    		Inhibitor 99.81%
    (rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.
  • HY-134819
    (1S,2S)-ML-SI3
    		Inhibitor 99.82%
    (1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a TRPML inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC50=5.9 μM), but an activator on TRPML 2 and 3 (EC50=2.7 μM/10.8 μM).
  • HY-162095
    TRPML1 agonist 1
    		Agonist
    TRPML1 agonist 1 (compound 18) is a potent TRPML1 agonist with an EC50 value of 0.27 µM.