2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Thrombin

Thrombin

Thrombin

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Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99465
    Befovacimab
    		Inhibitor
    Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research.
    Befovacimab
  • HY-B0375S
    Argatroban-d3
    		Inhibitor
    Argatroban-d3 is the deuterium labeled Argatroban. Argatroban (MD-805) is a direct, selective thrombin inhibitor.
    Argatroban-d<sub>3</sub>
  • HY-P4721
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM.
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
  • HY-123550
    Rosenonolactone
    		Inhibitor
    Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein.
    Rosenonolactone
  • HY-112995
    Lepirudin
    		Inhibitor
    Lepirudin is a potent irreversible thrombin inhibitor. Lepirudin also is a recombinant hirudin. Lepirudin has anticoagulation in heparin-induced thrombocytopenia (HIT).
    Lepirudin
  • HY-P5889
    Thrombin receptor peptide ligand
    		Antagonist
    Thrombin receptor peptide ligand is a thrombin receptor antagonist peptide that can be used as an antithrombotic agent.
    Thrombin receptor peptide ligand
  • HY-10270
    Flovagatran
    		Inhibitor
    Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.
    Flovagatran
  • HY-P4259
    Hirullin P18
    		Inhibitor
    Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect.
    Hirullin P18
  • HY-10273
    Atecegatran metoxil
    		Inhibitor
    Atecegatran metoxil is a oral anticoagulant, which inhibits thrombin factor II and is used in thromboembolic disorders. In vivo, Atecegatran metoxil is converted to AR-H067637, a selective and reversible direct thrombin inhibitor.
    Atecegatran metoxil
  • HY-109549
    Desirudin
    		Inhibitor
    Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction.
    Desirudin
  • HY-10274S
    Dabigatran etexilate-d13
    		Inhibitor ≥98.0%
    Dabigatran etexilate-d13 is the deuterium labeled Dabigatran etexilate. Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran. Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation[1].
    Dabigatran etexilate-d<sub>13</sub>
  • HY-14936
    Sofigatran
    		Inhibitor
    Sofigatran (MCC-977) is an orally active factor IIa (thrombin) inhibitor, acts as an anticoagulant. Sofigatran is used for the research of cardiovascular disease.
    Sofigatran
  • HY-N10582
    Aeruginosin 98-B
    		Inhibitor
    Aeruginosin 98-B is a protease inhibitor. Aeruginosin 98-B inhibits trypsin, plasmin and thrombin with IC50 values of 0.6, 7.0 and 10.0 μg/mL, respectively.
    Aeruginosin 98-B
  • HY-N10762
    15,16-Dihydrotanshindiol C
    		Inhibitor
    15,16-Dihydrotanshindiol C, a diterpenoid, is a potent thrombin inhibitor.
    15,16-Dihydrotanshindiol C
  • HY-P4475
    Sar-Pro-Arg-pNA
    Sar-Pro-Arg-pNA is a chromogenic substrate of α-thrombin. Sar-Pro-Arg-pNA can be used to test α-thrombin activity.
    Sar-Pro-Arg-pNA
  • HY-B0209R
    Metolazone (Standard)
    		Inhibitor
    Metolazone (Standard) is the analytical standard of Metolazone. This product is intended for research and analytical applications. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.
    Metolazone (Standard)
  • HY-12605
    SAR107375
    		Inhibitor
    SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively.
    SAR107375
  • HY-151983
    Thrombin inhibitor 6
    		Inhibitor
    Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant.
    Thrombin inhibitor 6
  • HY-151146
    (1R,3S)-THCCA-Asn
    		Inhibitor
    (1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.
    (1R,3S)-THCCA-Asn
  • HY-163348
    FXIIa-IN-4
    		Inhibitor
    FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC50 of 0.032 μM, 0.30 μM, ＞50 μM for FXIIa, thrombin and FXIa, respectively. FXIIa-IN-4 can be used for study of anticoagulant.
    FXIIa-IN-4
Cat. No. Product Name / Synonyms Application Reactivity