Thrombin

Related Products

Thrombin is a Na⁺-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Thrombin Related Products (86)
Antibodies (7)

By Effects:	Inhibitors (72) Agonist (1) Antagonists (3) Activators (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-12605

SAR107375	Inhibitor
SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively.

HY-151983

Thrombin inhibitor 6	Inhibitor
Thrombin inhibitor 6 is a potent thrombin inhibitor (IC₅₀: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant.

HY-151146

(1R,3S)-THCCA-Asn	Inhibitor
(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC₅₀ value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.

HY-10274AR

Dabigatran etexilate mesylate (Standard)	Inhibitor
Dabigatran etexilate (mesylate) (Standard) is the analytical standard of Dabigatran etexilate (mesylate). This product is intended for research and analytical applications. Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.

HY-163348

FXIIa-IN-4	Inhibitor
FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC₅₀ of 0.032 μM, 0.30 μM, ＞50 μM for FXIIa, thrombin and FXIa, respectively. FXIIa-IN-4 can be used for study of anticoagulant.

HY-129496

NP-313	Inhibitor	99.58%
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca²⁺ inward flow.

HY-P5371

TFLLRNPNDK-NH2	Activator
TFLLRNPNDK-NH2 is a biological active peptide. (This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.)

HY-P4593

Z-Gly-Pro-Arg-4MβNA
Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity.

HY-10163S3

Dabigatran-¹³C,d₃	Inhibitor
Dabigatran-¹³C,d₃ is the ¹³C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

HY-120563

LY135305	Inhibitor
LY 135305 is a thrombin activation inhibitor. LY 135305 inhibits spontaneous metastasis and increases animal survival.

HY-19373

RWJ-445167	Inhibitor
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-B0209S

Metolazone-d₇	Inhibitor	99.90%
Metolazone-d₇ is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.

HY-10264R

Edoxaban (Standard)	Inhibitor
Edoxaban (Standard) is the analytical standard of Edoxaban. This product is intended for research and analytical applications. Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_i values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research.

HY-10163S2

Dabigatran-¹³C₆
Dabigatran-¹³C₆ is the ¹³C labeled Dabigatran[1]. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[2][3].

HY-19691

Idraparinux sodium	Inhibitor
Idraparinux (sodium) is a polymethylated synthetic pentasaccharide known to interact with the antithrombin III and act as anticoagulant.

HY-162109

Thrombin inhibitor 11	Inhibitor
Thrombin inhibitor 11 is a thrombin inhibitor, with human and rat K_i values of 65 nM and 10.3 nM, respectively.

HY-100245

OM-189	Inhibitor
OM-189 is a selective synthetic thrombin inhibitor.

HY-107966

Heparin calcium (MW 15000-19000)	Inhibitor
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin.

HY-P1929R

Bivalirudin (Standard)	Inhibitor
Bivalirudin (Standard) is the analytical standard of Bivalirudin. This product is intended for research and analytical applications. Bivalirudin, a peptide anticoagulant, is a direct thrombin inhibitor for anticoagulation in the setting of invasive cardiology, particularly percutaneous coronary intervention.

HY-B0375S1

Argatroban-¹³C₆ hydrochloride	Inhibitor
Argatroban-¹³C₆ hydrochloride is ¹³C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.

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Thrombin

Thrombin

Thrombin Related Products (86)

Antibodies (7)

Thrombin Related Products (86):