1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

Toll-like Receptor (TLR)

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals. TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection. TLRs recognize highly conserved structural motifs known as pathogen-associated microbial patterns (PAMPs), which are exclusively expressed by microbial pathogens.

Toll-like Receptor (TLR) Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-11109
    TAK-242 Inhibitor
    TAK-242 is a novel small molecule TLR4 signaling inhibitor, selectively inhibits the TLR4-mediated production of cytokines and NO.
  • HY-17589
    Chloroquine diphosphate Inhibitor
    Chloroquine (diphosphate) is an antimalarial drug and autophagy/lysosome inhibitor, inhibiting Toll-like receptor (TLR) signalling.
  • HY-13740
    Resiquimod Agonist
    Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the levels of cytokines such as TNF-α, IL-6 and IFN-α.
  • HY-15601
    GS-9620 Agonist
    GS-9620 is a potent and selective orally active agonist of Toll-Like Receptor (TLR)7.
  • HY-13773
    Motolimod Agonist
    Motolimod is a selective Toll-like receptor (TLR) 8 agonist, with EC50 of about 100 nM.
  • HY-N0741
    Leonurine Inhibitor
    Leonurine, a natural alkaloid extracted from Herba leonuri, has been proved to have anti-inflammatory effect.
  • HY-N0741A
    Leonurine hydrochloride Inhibitor
    Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
  • HY-N0795
    Procyanidin B1 Antagonist
    Procyanidin B1 , inhibits infection by vesicular stomatitis virus and HCV pseudotype virus in Huh-7 cells, with IC50 of 29(mu)M and 15(mu)M, respectively.
  • HY-B0180
    Imiquimod Agonist
    Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
  • HY-N0201
    Atractylenolide I Antagonist
    Atractylenolide I is a natural compound extracted from largehead atractylodes rhizome; induce apoptosis and bring about cytotoxicity of human promyeloleukemic HL-60 cells; TLR4-antagonizing agent.
  • HY-10018
    Toll-like receptor modulator Modulator
    A Toll-like receptor modulator.
  • HY-B0180A
    Imiquimod hydrochloride Agonist
    Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
  • HY-B0180B
    Imiquimod maleate Agonist
    Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.