Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Tyrosinase Related Products (130)
Antibodies (7)

By Effects:	Inhibitors (116) Antagonist (1) Activators (3) Modulator (1) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P3662

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Activator	99.95%
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model.

HY-21290

SU-4942	Modulator	98.55%
SU-4942 is a tyrosine kinase signal signal modulator. SU-4942 inhibits VEGF- and endothelial cell growth factor (ECGF)-induced mitogenesis in endothelial cells (US5792783A).

HY-W013636S1

2-Ketoglutaric acid-d₄
2-Ketoglutaric acid-d₄ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636B

Calcium 2-oxoglutarate	Inhibitor	≥98.0%
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-N0136B

(-)-Taxifolin	Inhibitor
(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-N6244

Isolindleyin	Inhibitor	≥99.0%
Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities.

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Inhibitor	99.08%
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 29.75 μM.

HY-W099579

Kojic acid dipalmitate	Inhibitor	99.84%
Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research.

HY-N8223

Viscumneoside III	Inhibitor	≥98.0%
Viscumneoside III, a dihydroflavone O-glycoside, is a potent tyrosinase inhibitor with an IC₅₀ of 0.5 mM. Viscumneoside III has anti-angina pectoris.

HY-N2101

Benzoyloxypaeoniflorin	Inhibitor	98.65%
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation.

HY-P3813

Tyrosinase (206-214), human		98.35%
Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL).

HY-Y0444S1

D-Tyrosine-d₄	Inhibitor	≥99.0%
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-P3452

Tetrapeptide-30	Inhibitor	≥98.0%
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation.

HY-Y0729

4-Chlorocinnamic acid	Inhibitor	99.98%
4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth.

HY-N3518

Mulberroside F	Inhibitor	99.37%
Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L.). Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation. Mulberroside F also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation.

HY-W015782

4-Ethylresorcinol	Inhibitor	99.71%
4-Ethylresorcinol, a derivative of resorcinol, can act as substrates of tyrosinase. 4-Ethylresorcinol possess hypopigmentary effects. 4-Ethylresorcinol attenuates mRNA and protein expression of tyrosinase-related protein (TRP)-2, and possessed antioxidative effect by inhibiting lipid peroxidation.

HY-143450

Tyrosinase-IN-3	Inhibitor
Tyrosinase-IN-3 (compound 54) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-3 has the potential for the research of skin whitening agents and food preservatives.

HY-143459

Tyrosinase-IN-5	Inhibitor
Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of tyrosinase with an IC₅₀ of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells.

HY-149404

Tyrosinase-IN-12		99.83%
Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, non-competitive tyrosinase inhibitor with an IC₅₀ value of 49.33 ± 2.64 µM and K_i value of 31.25 ± 0.25 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) have the highest radical scavenging activity to reduce the production of reactive oxygen species (ROS) with an IC₅₀ value of 25.39 ± 0.77 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) can be used for anti-browning substances in the food and agricultural sectors.

HY-143448

Tyrosinase-IN-1	Inhibitor
Tyrosinase-IN-1 (compound 90) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-1 has the potential for the research of skin whitening agents and food preservatives.

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Tyrosinase

Tyrosinase

Tyrosinase Related Products (130)

Antibodies (7)

Tyrosinase Related Products (130):