2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. ClpP
  5. ClpP Inhibitor

ClpP Inhibitor

ClpP Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-111532
    (3R,4R)-A2-32-01
    		Inhibitor 99.43%
    (3R,4R)-A2-32-01 (compound 24(R,R)), the (R,R)-enantiomer of A2-32-01, is a Staphylococcus aureus caseinolytic protease (SaClpP) inhibitor.
  • HY-111532B
    (3S,4S)-A2-32-01
    		Inhibitor 98.15%
    (3S,4S)-A2-32-01 (compound 24(S,S)), a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor.
  • HY-152097
    (S)-ZG197
    		Inhibitor
    (S)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC50 of 1.4 μM.
  • HY-152096
    (R)-ZG197
    		Inhibitor
    (R)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC50 of 1.5 μM. (R)-ZG197 also activates Homo sapiens ClpP (HsClpP) with an EC50 of 31.4 μM.
  • HY-155556
    ZG36
    		Inhibitor
    ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model.