2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dihydrofolate reductase (DHFR)

Dihydrofolate reductase (DHFR)

Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate using NADPH, and it is involved in the synthesis of nucleotide, in both prokaryotic and eukaryotic cells. DHFR inhibitors are commonly used for fighting malaria and other protozoal infections, as well as for treating fungal, bacterial, and mycobacterial infections.

Dihydrofolate reductase (DHFR) Related Products (29):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-161064
    DHFR-IN-15
    		Inhibitor
    DHFR-IN-15 (compound 34) is a dihydrofolate reductase (DHFR) inhibitor with potential anticancer activity. DHFR-IN-15 effectively binds to DHFR in cells, reducing DHFR levels to 10 nM.
    DHFR-IN-15
  • HY-124350
    10-Formylfolic acid
    		Inhibitor
    10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia.
    10-Formylfolic acid
  • HY-161010
    DHFR-IN-13
    		Inhibitor
    DHFR-IN-13 (Compd Hit8) is an active R. solani DHFR inhibitor with an IC50 value of 10.2 μM. DHFR-IN-13 has selectivity of inhibition against human DHFR with an IC50 value of 227.7 μM. DHFR-IN-13 also is a fungicide. DHFR-IN-13 has high antifungal activity against R. solani with EC50 value of 38.2 mg/L.
    DHFR-IN-13
  • HY-125647
    10-Deazaaminopterin
    		Inhibitor
    10-Deazaaminopterin is a potent inhibitor of dihydrofolate reductase. 10-Deazaaminopterin can used in study advanced cancer.
    10-Deazaaminopterin
  • HY-161292
    DHFR-IN-16
    		Inhibitor
    DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) (IC50=0.199 μM) and can be used in anti-infectious research.
    DHFR-IN-16
  • HY-149459A
    Phototrexate
    		Inhibitor
    Phototrexate is a photoswitchable inhibitor of the human dihydrofolate reductase (DHFR). Phototrexate has antifolate and antiproliferative properties, which can be used for the research of cancer.
    Phototrexate
  • HY-156414
    DHFR-IN-11
    		Inhibitor
    DHFR-IN-11 (compound 6b) is inhibitor of DHFR, and has inhibitory potency versus M. tuberculosis DHFR enzyme with IC50 values 5.70 μM.
    DHFR-IN-11
  • HY-161063
    DHFR-IN-14
    		Inhibitor
    DHFR-IN-14 (compound 32) is a pyrimethamine (Pyr)-type, dihydrofolate reductase (DHFR) inhibitor with potential anticancer activity.
    DHFR-IN-14
  • HY-149699
    DHFR-IN-12
    		Inhibitor
    DHFR-IN-12 (Compound 5c) is a DHFR inhibitor which has good antibacterial activity.
    DHFR-IN-12