2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. AA29504

AA29504 is a ethyl carbamate with γ-aminobutyric acid (GABAA(HY-L120) receptor activity. AA29504 inhibits the delivery of the neurotransmitter gamma-aminobutyric acid in the central nervous system. AA29504 can be used to research anxiety, insomnia and other neuropsychiatric diseases .

For research use only. We do not sell to patients.

AA29504 Chemical Structure

AA29504 Chemical Structure

CAS No. : 945828-50-2

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Based on 1 publication(s) in Google Scholar

AA29504 Related Antibodies

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Description

AA29504 is a ethyl carbamate with γ-aminobutyric acid (GABAA(HY-L120) receptor activity. AA29504 inhibits the delivery of the neurotransmitter gamma-aminobutyric acid in the central nervous system. AA29504 can be used to research anxiety, insomnia and other neuropsychiatric diseases [1].

In Vitro

AA29504 (0.1, 1, 10, 100 μM, 72 h) can open the Kv7 voltage-gated K+ channels (KCNQ) in Xenopus oocytes [1].
AA29504 (1 μM) positively regulates GABAA receptors expressed in Xenopus oocytes, EC501.4 μM[1] .
AA29504 (1 μM, 10 s) significantly enhances the gaboxadol-mediated current in pyramidal neurons of the prefrontal cortex[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AA29504 Related Antibodies
In Vivo

AA29504 (0.5, 2 or 4 mg/kg, subcutaneously injection) has antianxiety effects in male SD (Spraguee Dawley) rats[1].
AA29504 (4 mg/kg, subcutaneous injection) significantly weakenes the motor coordination of male SD rats under the synergistic effect of alcohol [1].
AA29504 (2.5, 5 and 10 mg/kg, subcutaneously injection) has therapeutic effect on amygdala ignited seizures in male Wistar rats [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Spraguee Dawley rats [1]
Dosage: 0.5, 2 or 4 mg/kg
Administration: Subcutaneous injections
Result: Reduced the number of vocalizations at 4 mg/kg and reversed partially the freezing behavior at 2 mg/kg.
Animal Model: Male Spraguee Dawley rats [1]
Dosage: 4 mg/kg
Administration: Subcutaneous injections
Result: Reduced the time the rats stayed on the rotarod at 4 mg/kg.
Animal Model: Male Wistar rats [1]
Dosage: 10 mg/kg
Administration: Subcutaneous injections
Result: Reduced from 4.9 to 2.0 in amygdala kindled seizures response.
Molecular Weight

327.42

Formula

C19H25N3O2
CAS No.
SMILES

O=C(NC1=CC=C(NCC2=C(C)C=C(C)C=C2C)C=C1N)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AA29504 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AA29504945828-50-2AA 29504AA-29504GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorXenopus oocytespyramidal cells ofprefrontal cortexGABAA receptorInhibitorinhibitorinhibit

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