2. Protein Tyrosine Kinase/RTK Apoptosis JAK/STAT Signaling
  3. EGFR Anaplastic lymphoma kinase (ALK) Apoptosis
  4. ALK/EGFR-IN-1

ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research.

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ALK/EGFR-IN-1 Chemical Structure

ALK/EGFR-IN-1 Chemical Structure

CAS No. : 2730430-08-5

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Other Forms of ALK/EGFR-IN-1:

ALK/EGFR-IN-1 Related Antibodies

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Description

ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research[1].

Molecular Weight

572.12

Formula

C27H34ClN7O3S
CAS No.
SMILES

O=S(CC)C1=C(NC2=NC(NC3=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C3)=NC=C2Cl)C=CC=C1
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ALK/EGFR-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK/EGFR-IN-12730430-08-5EGFRAnaplastic lymphoma kinase (ALK)ApoptosisEpidermal growth factor receptorErbB-1HER1Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246NSCLCantitumorL858RT790MH1975H2228Inhibitorinhibitorinhibit

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