Amiodarone-d₁₀ hydrochloride

Name: Amiodarone-d 10 hydrochloride
Brand: MedChemExpress
SKU: HY-14187S
Rating: 4.5 (1 reviews)

Cat. No.: HY-14187S Purity: 98.81%: FAQs
Data Sheet SDS COA Handling Instructions

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Amiodarone-d₁₀ (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].

For research use only. We do not sell to patients.

Amiodarone-d<sub>10</sub> hydrochloride Chemical Structure

Amiodarone-d₁₀ hydrochloride Chemical Structure

CAS No. : 1261393-77-4

Size	Price	Stock	Quantity
1 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Amiodarone-d₁₀ hydrochloride:

Amiodarone Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

691.83

Formula

C₂₅H₂₀D₁₀ClI₂NO₃

CAS No.

1261393-77-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC(I)=C(C(I)=C1)OCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])C2=C(CCCC)OC3=CC=CC=C23.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (289.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4454 mL	7.2272 mL	14.4544 mL
5 mM	0.2891 mL	1.4454 mL	2.8909 mL
10 mM	0.1445 mL	0.7227 mL	1.4454 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.81%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) HNMR (118 KB) RP-HPLC (163 KB) LCMS (382 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67. [Content Brief]

[3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4454 mL	7.2272 mL	14.4544 mL	36.1360 mL
	5 mM	0.2891 mL	1.4454 mL	2.8909 mL	7.2272 mL
	10 mM	0.1445 mL	0.7227 mL	1.4454 mL	3.6136 mL
	15 mM	0.0964 mL	0.4818 mL	0.9636 mL	2.4091 mL
	20 mM	0.0723 mL	0.3614 mL	0.7227 mL	1.8068 mL
	25 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4454 mL
	30 mM	0.0482 mL	0.2409 mL	0.4818 mL	1.2045 mL
	40 mM	0.0361 mL	0.1807 mL	0.3614 mL	0.9034 mL
	50 mM	0.0289 mL	0.1445 mL	0.2891 mL	0.7227 mL
	60 mM	0.0241 mL	0.1205 mL	0.2409 mL	0.6023 mL
	80 mM	0.0181 mL	0.0903 mL	0.1807 mL	0.4517 mL
	100 mM	0.0145 mL	0.0723 mL	0.1445 mL	0.3614 mL